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Phytochemical screening, molecular docking, antifertility investigations, and ADME potential of various extracts of leaves.
J Complement Integr Med
December 2024
National Forensic Sciences University, Ponda, Goa, India.
Article Synopsis
- The study aimed to investigate the molecular docking characteristics and antifertility effects of extracts derived from PO leaves, specifically petroleum ether and chloroform extracts.
- Using molecular docking software and animal models, researchers found that the petroleum ether extract (PEEPO) had a stronger anti-implantation effect than the chloroform extract (CHEPO) at various doses.
- The results suggested that both extracts are safe at high dosages, increase blood estrogen levels, and interact favorably with estrogen receptors, indicating their potential for developing herbal antifertility treatments.
A review on the traditional uses, nutritive importance, pharmacognostic features, phytochemicals, and pharmacology of Hook F.
PeerJ
March 2024
Pharmacognosy Department, Faculty of Pharmacy, University of Sadat City, Sadat City, Egypt.
Hook F. (MC), belonging to the family Cucurbitaceae, is a plant with several biological activities. This detailed, comprehensive review gathers and presents all the information related to the geographical distribution, morphology, therapeutic uses, nutritional values, pharmacognostic characters, phytochemicals, and pharmacological activities of MC.
View Article and Find Full Text PDFMolecular Docking Studies of Phyllanthus niruri Root Phytoconstituents for Antibreast Cancer Activity Using Multiple Proteins.
Adv Exp Med Biol
August 2023
Department of Pharmaceutical Chemistry, Institute of Pharmaceutical Technology, Sri Padmavathi Mahila Vishwavidyalaya, Tirupati, India.
The systematic exploitation of the structural variety of natural products is made possible by docking studies, which have been shown to be a crucial technique. The objective of the current work was to use molecular docking studies with different proteins to identify acceptable and efficient compounds from root phytoconstituents of Phyllanthus niruri plant. Numerous human disorders have been treated using Phyllanthus niruri.
View Article and Find Full Text PDFScreening of Phyllanthus niruri Leaves Phytoconstituents for Antiviral and Antibacterial Activity by Molecular Docking Studies.
Adv Exp Med Biol
November 2023
Gitam Institute of Science, Gitam Deemed University, Visakhapatnam, Andhra Pradesh, India.
The genus Phyllanthus belongs to one of the largest plant families, the Phyllantaceae (L.). Phyllanthus niruri is an annual perennial herb that grows in tropical Asia, America, China, and the islands of the Indian Ocean.
View Article and Find Full Text PDFPharmacognostic Profile and Screening of Anti-Proliferative Potential of Methanolic Extract of Plant on WRL-68 Cell Line and Function of Polycystin-1.
Arch Razi Inst
April 2022
Ministry of Education, Iraq.
is a medicinal plant that plays a crucial role in health care programs, especially in developing countries, and had anti-tumor, anti-inflammatory, anti-fertility, anti-bacterial, and other therapeutic effects. This study was designed to determine the anti-proliferative effects of methanolic extract of on the WRL-68 cell line and the function of polycystin-1 (PC-1). The half-maximal inhibitory concentration (IC) values were recorded in WRL-68 and AsPC-1 cell lines as 193 µg/ml and 149.
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