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Device-assisted strategies for drug delivery across the blood-brain barrier to treat glioblastoma.
Commun Mater
January 2025
Department of Biology, Emory University, Atlanta, GA USA.
The blood-brain barrier, essential for protecting the central nervous system, also restricts drug delivery to this region. Thus, delivering drugs across the blood-brain barrier is an active research area in immunology, oncology, and neurology; moreover, novel methods are urgently needed to expand therapeutic options for central nervous system pathologies. While previous strategies have focused on small molecules that modulate blood-brain barrier permeability or penetrate the barrier, there is an increased focus on biomedical devices-external or implanted-for improving drug delivery.
View Article and Find Full Text PDFTele-medicine and its impact on academic medical centers: A narrative review.
J Family Med Prim Care
December 2024
Department of Internal Medicine, Creighton University School of Medicine, Omaha, NE, USA.
Telemedicine is a potential complementary modality with remarkable benefits for future healthcare delivery when incorporated appropriately. This review article examines the importance of telemedicine in various types of healthcare facilities and its utility in remote and underserved settings. PubMed, Google Scholar, Scopus, and Embase databases were used for the literature review.
View Article and Find Full Text PDFA Retrospective Data Analysis on Marine Animal Injuries at a Large, Multi-Site Medical System.
HCA Healthc J Med
December 2024
Grand Strand Medical Center, Myrtle Beach, SC.
Background: With increasing numbers of human-animal interactions, there has been an increase in animal-related injuries. While canine bites are the most commonly reported animal injury, little data exists in regard to the other classes of animals, particularly marine life. The last comprehensive report on injuries related to noncanine bites and stings seen in emergency departments (EDs) across the US was between 2011 and 2015.
View Article and Find Full Text PDFTotal Aortic Arch Endograft and Double In Situ Fenestration for Aortobronchial Fistula.
Ann Thorac Surg Short Rep
March 2024
Division of Vascular Surgery, Department of Surgery, University of Calgary, Calgary, Alberta, Canada.
This case highlights the challenges of treating an aortobronchial fistula. Emergent total aortic arch stent grafting is limited by inability to maintain cerebral perfusion during in situ fenestration. We describe the application of a new technique to maintain cerebral perfusion using a gutter balloon adjacent to the aortic endograft while great vessel fenestrations are being performed in an urgent setting.
View Article and Find Full Text PDFService evaluation of 'GP at Door' of accident and emergency services in Eastern England.
Prim Health Care Res Dev
January 2025
Norwich Medical School, University of East Anglia, Norwich, UK.
Aim: We describe activity, outcomes, and benefits after streaming low urgency attenders to eneral practice services at oor of ccident and mergency departments (GDAE).
Background: Many attendances to A&Es are for non-urgent health problems that could be better met by primary care rather than urgent care clinicians. It is valuable to monitor service activity, outcomes, service user demographics, and potential benefits when primary care is co-located with A&E departments.
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