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Gut microbiota modulates depressive-like behaviors induced by chronic ethanol exposure through short-chain fatty acids.
J Neuroinflammation
November 2024
Department of Forensic Pathology, China Medical University School of Forensic Medicine, No. 77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, 110122, P. R. China.
Background: Chronic ethanol exposure (CEE) is recognized as an important risk factor for depression, and the gut-brain axis has emerged as a key mechanism underlying chronic ethanol exposure-induced anxiety and depression-like behaviors. Short-chain fatty acids (SCFAs), which are the key metabolites generated by gut microbiota from insoluble dietary fiber, exert protective roles on the central nervous system, including the reduction of neuroinflammation. However, the link between gut microbial disturbances caused by chronic ethanol exposure, production of SCFAs, and anxiety and depression-like behaviors remains unclear.
View Article and Find Full Text PDFAsiaticoside improves depressive-like behavior in mice with chronic unpredictable mild stress through modulation of the gut microbiota.
Front Pharmacol
October 2024
Pharmaceutical Technology Key Laboratory of Luzhou, Central Nervous System Drug Key Laboratory of Sichuan Province, School of Pharmacy, Southwest Medical University, Luzhou, China.
Background: Asiaticoside, the main active ingredient of Centella asiatica, is a pentacyclic triterpenoid compound. Previous studies have suggested that asiaticoside possesses neuroprotective and anti-depressive properties, however, the mechanism of its anti-depressant action not fully understood. In recent years, a growing body of research on anti-depressants has focused on the microbiota-gut-brain axis, we noted that disruption of the gut microbial community structure and diversity can induce or exacerbate depression, which plays a key role in the regulation of depression.
View Article and Find Full Text PDFChemical constituents, pharmacological activities and quality evaluation methods of genus : A comprehensive review.
Chin Herb Med
July 2024
College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
The genus is a multi-origin animal species with high medicinal and healthcare values. About 57 species of spread worldwide, of which about 14 species can be used as medicine, showing anti-oxidation, anti-inflammation, anti-depressant, anti-hypertension, anti-prostatic hyperplasia, antivirus, anti-apoptotic, antifatigue, and so on. And those pharmacological effects are mainly related to their active ingredients, including amino acids, abundant proteins (peptides and oligopeptides), fatty acids, nucleosides, steroids, and other small molecular compounds.
View Article and Find Full Text PDFContemporary Views of the Extraction, Health Benefits, and Industrial Integration of Rice Bran Oil: A Prominent Ingredient for Holistic Human Health.
Foods
April 2024
School of Food, Biological Engineering Jiangsu University, Zhenjiang 212013, China.
Globally, 50% of people consume rice (), which is among the most abundant and extensively ingested cereal grains. Rice bran is a by-product of the cereal industry and is also considered a beneficial waste product of the rice processing industry. Rice bran oil (RBO) is created from rice bran (20-25 wt% in rice bran), which is the outermost layer of the rice kernel; has a lipid content of up to 25%; and is a considerable source of a plethora of bioactive components.
View Article and Find Full Text PDFChemical and biochemical characterization of : genoprotective potential and inhibitory mechanism of its phytochemicals against α-amylase and α-glucosidase.
Front Nutr
December 2023
Department of Biotechnology, Gauhati University, Guwahati, Assam, India.
also known as water spinach, is an aquatic non-conventional leafy vegetable and is considered a healthy and seasonal delicacy in ethnic food culture. The study revealed the presence of rich chemical and biochemical composition in and antioxidant activities. Moreover, the plant extracts demonstrated significant DNA damage prevention activity against UV/HO-induced oxidative damage.
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