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The Role of Radiation, Immunotherapy, and Chemotherapy in the Management of Locally Advanced or Metastatic Cutaneous Malignancies.
Cancers (Basel)
November 2024
New York Proton Center, New York, NY 10035, USA.
Introduction: Skin cancer impacts a significant proportion of the population. While surgical management is often the mainstay of treatment, advanced or metastatic cutaneous malignancies require additional local and/or systemic therapies.
Methods: A review of the literature was performed studying the use of radiation therapy, chemotherapy, and immunotherapy for locally advanced or metastatic cutaneous malignancies.
Genomic profiles and prognostic biomarkers in patients with acute myeloid leukemia (AML) from ancestry-diverse populations are underexplored. We analyzed the exomes and transcriptomes of 100 patients with AML with genomically confirmed African ancestry (Black; Alliance) and compared their somatic mutation frequencies with those of 323 self-reported white patients with AML, 55% of whom had genomically confirmed European ancestry (white; BeatAML). Here we find that 73% of 162 gene mutations recurrent in Black patients, including a hitherto unreported PHIP alteration detected in 7% of patients, were found in one white patient or not detected.
View Article and Find Full Text PDFAssessing external exposome by implementing an Environmental Data Management System using Open Data.
Sci Rep
July 2024
Dept of Pneumology, Allergology and Thoracic Oncology, CHU, Montpellier, France.
Due to the increasing importance of exposome in environmental epidemiology, feasibility and usefulness of an Environmental Data Management System (EDMS) using Open Data was evaluated. The EDMS includes data from 10 European cities (Celje (Slovenia), Łódź (Poland), Manchester (UK), Palermo (Italy), Paris (France), Porto (Portugal), Regensburg (Germany), Reus (Spain), Rijeka (Croatia), Thessaloniki (Greece)) about external non-specific and specific exposome factors at the city or country level (2017-2020). Findings showed that the highest values of life expectancy were in Reus females (86 years) and Palermo males (81 years).
View Article and Find Full Text PDFKey factors for establishing and sustaining a successful palliative radiation oncology program: a survey of the Society for Palliative Radiation Oncology.
Ann Palliat Med
July 2024
Department of Radiation Oncology, University of Arizona, College of Medicine-Tucson, Tucson, AZ, USA.
Article Synopsis
- Dedicated palliative radiation oncology programs (PROPs) improve the quality of radiation therapy for advanced cancer patients, but there are few existing programs, showing a need to explore their characteristics and the challenges in starting and sustaining them.
- A survey of 157 members from the Society of Palliative Radiation Oncology revealed that while 89% of respondents see the importance of developing PROPs, only 36% currently have one, with many expressing a desire to establish or develop programs.
- Key resources for successful PROPs include access to specialist-level palliative care, support from advanced practice providers, and a focus on short radiation courses, alongside opportunities for education in palliative care.
Factors limiting the potential range expansion of lodgepole pine in Interior Alaska.
Ecol Appl
July 2024
Institute of Arctic Biology, University of Alaska, Fairbanks, Alaska, USA.
Understanding the factors influencing species range limits is increasingly crucial in anticipating migrations due to human-caused climate change. In the boreal biome, ongoing climate change and the associated increases in the rate, size, and severity of disturbances may alter the distributions of boreal tree species. Notably, Interior Alaska lacks native pine, a biogeographical anomaly that carries implications for ecosystem structure and function.
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