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Protein Kinase C Isozyme Immaturity/Deficiency in Cord Blood Monocytes and Neutrophils.
Int J Mol Sci
October 2024
Department of Immunopathology, SA Pathology at the Women's and Children's Hospital, North Adelaide, SA 5006, Australia.
Article Synopsis
- Reduced levels of Protein Kinase C (PKC)ζ in cord blood T cells are linked to the development of allergies in children and a tendency to favor an immature T-helper (Th)2 cytokine response.* -
- Cord blood monocytes and neutrophils also exhibit low levels of various PKC isozymes compared to adult blood, indicating a broader deficiency in these immune cells.* -
- While PKCζ levels in cord blood T cells correlate with those in monocytes, this does not influence the differentiation of the T cells towards Th1 or Th2 cytokine profiles, unlike in T cells.*
MAIT Cells in the Bone Marrow of Patients with Aplastic Anemia.
Int J Mol Sci
September 2024
Division of Hematology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute 480-1195, Japan.
Mucosal-associated invariant T cells (MAIT cells) are a subset of T cells with innate, effector-like properties that play an essential role in the immune response to microbial infections. In humans, MAIT cells are detectable in the blood, liver, and lungs, but little is known about the frequency of these cells in the bone marrow. Also, the pathogenic role, if any, of MAIT cells in the development of aplastic anemia, a disease with an exquisite origin in the bone marrow, is currently unknown.
View Article and Find Full Text PDFLow levels of CD26 on certain cellular subtypes of donor harvest is associated with better clinical outcomes post allogeneic stem cell transplantation through regulation of NF-κB pathway and pro-inflammatory cytokines.
Int Immunopharmacol
December 2023
Kode Lab, Tumor Immunology & Immunotherapy Group, Advanced Centre for Treatment, Research & Education in Cancer, Tata Memorial Centre, Kharghar, Navi Mumbai 410210, India; Homi Bhabha National Institute (HBNI), Training School Complex, Anushakti Nagar, Mumbai 400094, India. Electronic address:
Article Synopsis
- The study investigates the role of CD26, a surface protein, and related molecules in immune responses and outcomes in patients undergoing allogeneic stem cell transplantation (ASCT), building on previous findings linking CD26 to acute Graft-versus-Host-Disease (aGVHD).
- A cohort of 26 transplant donors/patients was analyzed, focusing on the expression of CD26 and other immune markers, while examining their association with clinical outcomes within the context of aGVHD and chronic GVHD (cGVHD).
- Results indicate that higher CD26 expression in donor cells and altered immune profiles post-transplant, such as decreased B cells and increased myeloid dendritic and CD3T cells, are correlated with higher
PpSP32, the Phlebotomus papatasi immunodominant salivary protein, exerts immunomodulatory effects on human monocytes, macrophages, and lymphocytes.
Parasit Vectors
January 2023
Laboratory of Transmission, Control and Immunobiology of Infections (LTCII), LR11IPT02, Pasteur Institute de Tunis, Tunis, Tunisia.
Background: The saliva of sand flies, vectors of Leishmania parasites, contains several components that exert pharmacological activity facilitating the acquisition of blood by the insect and contributing to the establishment of infection. Previously, we demonstrated that PpSP32 is the immunodominant salivary antigen in humans exposed to Phlebotomus papatasi bites and validated its usefulness as a predictive biomarker of disease. PpSP32, whose functions are little known to date, is an intriguing protein due to its involvement in the etiopathogenesis of pemphigus, an auto-immune disease.
View Article and Find Full Text PDFComparison of [H]-Thymidine, Carboxyfluorescein Diacetate Succinimidyl Ester and Ki-67 in Lymphocyte Proliferation.
Front Pediatr
April 2022
Primary Immunodeficiency Care and Research (PICAR) Institute, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan.
Background: Patients with T cell deficiency <10% of normal proliferation are indicated to receive immune reconstruction by hematopoietic stem cell transplantation (HSCT). This study aimed to investigate whether non-radioactive assays can be used to quantitatively detect the lymphocyte proliferation <10% of normal as radioactive [H]-thymidine."
Methods: Radioactive [H]-thymidine, non-radioactive carboxyfluorescein diacetate succinimidyl ester (CFSE), and Ki-67 protein expressions were used to measure the lymphocyte proliferation as calculated using the stimulation index (SI), subtraction percentage, and proliferation index (FlowJo software).
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