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The bridging role of soil organic carbon in regulating bacterial community by microplastic pollution: Evidence from different microplastic additions.
J Hazard Mater
February 2025
Eco-environmental Protection Research Institute, Shanghai Academy of Agricultural Sciences, Shanghai 201403, China; Key Laboratory of Low-carbon Green Agriculture in Southeastern China, Ministry of Agri-culture and Rural Affairs, Shanghai 201403, China. Electronic address:
The serious threat posed by microplastics pollution to soil ecosystems and human health has attracted worldwide attention. Microplastics of different types are present in the soil environment, whereas research about the effects of different microplastics on soil ecology are limited. This study sought to determine how three common microplastics (polyethylene (PE), polystyrene (PS), and polyvinyl chloride (PVC)) affect soil physicochemical characteristics, enzyme activities, bacterial community, and their metabolic pathways at a 1 % w/w concentration.
View Article and Find Full Text PDFThe effect of the aging processes of Ulva prolifera-derived dissolved organic nitrogen associated with green tide on the diatoms-dinoflagellates succession in the Southern Yellow Sea, China.
Water Res
February 2025
Frontiers Science Center for Deep Ocean Multispheres and Earth System, and Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, Ocean University of China, Qingdao 266100, China; College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 2066061, China. Electronic address:
Multitudinous dissolved organic nitrogen (DON) enters seawater from Ulva prolifera green tides impacting phytoplankton community structure in the Yellow Sea. Field investigations and cultural experiments on U. prolifera-derived DON aging revealed its regulatory effects.
View Article and Find Full Text PDFEffect of Biofloc Culture on the Daily Rhythmicity of the Activity and Expression of Digestive Enzymes in Tilapia, .
Aquac Nutr
January 2025
Departamento El Hombre y su Ambiente, Universidad Autónoma Metropolitana-Unidad Xochimilco, Calzada del Hueso # 1100, Ciudad de México 04960, Mexico.
Biofloc technology (BFT) has recently attracted great attention due to minimal water exchange and reduced feed intake. This study aimed to recognize daily changes in the digestive physiology of between a traditional system and BFT. The enzyme activity of trypsin (try), chymotrypsin (chy), leucine aminopeptidase (lap), alkaline proteases (alk), lipase (lip), and amylase (amy), along with the gene expression of trypsin (), chymotrypsin (), pepsin (), amylase (), and phospholipase () were measured throughout a daily cycle.
View Article and Find Full Text PDFPreviously, a novel series of leucine ureido derivatives containing the 1,2,3-triazole moiety were identified and validated as potent aminopeptidase N inhibitors with marked and antitumor potencies. Moreover, synergistic anti-proliferation effects against tumor cells were found when used in combination with 5-Fluorouracil (5-FU). Herein, a novel leucine ureido derivative (compound 3) was synthesized by coupling cytotoxic agent 5-FU with leucine ureido derivatives containing the 1,2,3-triazole moiety esterification.
View Article and Find Full Text PDFDiscovery of New Nanomolar Selective IRAP Inhibitors.
J Med Chem
February 2025
Univ. Lille, Inserm, Institut Pasteur de Lille, U1177 - Drugs and Molecules for Living Systems, F-59000 Lille, France.
Among the M1 family of oxytocinase aminopeptidases, insulin-regulated aminopeptidase IRAP, is an emerging drug target implicated in various biological pathways and particularly in MHC-I antigen presentation through amino-terminal trimming of exogenous cross-presented peptides. A few series of inhibitors inspired either by angiotensin IV, one of IRAP substrates, or by bestatin a pan aminopeptidase inhibitor, have been disclosed. However, the variety and number of chemotypes remains relatively limited.
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