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Identification and Analysis of Biomarkers Associated with Lipophagy and Therapeutic Agents for COVID-19.
Viruses
June 2024
Institute of Tropical Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
Background: Lipids, as a fundamental cell component, play an regulating role in controlling the different cellular biological processes involved in viral infections. A notable feature of coronavirus disease 2019 (COVID-19) is impaired lipid metabolism. The function of lipophagy-related genes in COVID-19 is unknown.
View Article and Find Full Text PDFTargeting ZDHHC21/FASN axis for the treatment of diffuse large B-cell lymphoma.
Leukemia
February 2024
Medical Center of Hematology, Xinqiao Hospital, Army Medical University, Chongqing, China.
S-palmitoylation is essential for cancer development via regulating protein stability, function and subcellular location, yet the roles S-palmitoylation plays in diffuse large B-cell lymphoma (DLBCL) progression remain enigmatic. In this study, we uncovered a novel function of the palmitoyltransferase ZDHHC21 as a tumor suppressor in DLBCL and identified ZDHHC21 as a key regulator of fatty acid synthetase (FASN) S-palmitoylation for the first time. Specifically, ZDHHC21 was downregulated in DLBCL, and its expression level was associated with the clinical prognosis of patients with DLBCL.
View Article and Find Full Text PDFLanatoside C inhibits herpes simplex virus 1 replication by regulating NRF2 distribution within cells.
Phytomedicine
February 2024
Department of Pain Medicine and Shenzhen Municipal Key Laboratory for Pain Medicine, National Key Clinic of Pain Medicine, Shenzhen Nanshan People's Hospital, and the 6th Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen 518060, China. Electronic address:
Background: In the past decades, extensive research has been conducted to identify new drug targets for the treatment of Herpes simplex virus type 1 (HSV-1) infections. However, the emergence of drug-resistant HSV-1 strains remains a major challenge. This necessitates the identification of new drugs with novel mechanisms of action.
View Article and Find Full Text PDFTranscriptome Profiling of Cardiac Glycoside Treatment Reveals EGR1 and Downstream Proteins of MAPK/ERK Signaling Pathway in Human Breast Cancer Cells.
Int J Mol Sci
November 2023
Department of Computer Science, Virginia Commonwealth University, Richmond, VA 23284, USA.
Cardiac glycosides (CGs) constitute a group of steroid-like compounds renowned for their effectiveness in treating cardiovascular ailments. In recent times, there has been growing recognition of their potential use as drug leads in cancer treatment. In our prior research, we identified three highly promising CG compounds, namely lanatoside C (LC), peruvoside (PS), and strophanthidin (STR), which exhibited significant antitumor effects in lung, liver, and breast cancer cell lines.
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