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Int J Mol Sci
December 2024
Biotechnology Center, The Silesian University of Technology, 44-100 Gliwice, Poland.
Biomimetic natural biomaterial (BNBM) nanocomposite scaffolds for bone replacement can reduce the rate of implant failure and the associated risks of post-surgical complications for patients. Traditional bone implants, like allografts, and autografts, have limitations, such as donor site morbidity and potential patient inflammation. Over two million bone transplant procedures are performed yearly, and success varies depending on the material used.
View Article and Find Full Text PDFCureus
November 2024
Medical Education and Simulation, Maidstone and Tunbridge Wells National Health Service (NHS) Trust, Kent, GBR.
Background Many newly qualified doctors feel unprepared for clinical practice. The literature identifies themes including difficulties with clinical reasoning, emergency management, handover, and prioritization of tasks. Although there is an expected level of anxiety for newly qualified doctors, this appears to be amplified with respect to the first on-call shifts that encompass these themes.
View Article and Find Full Text PDFPain Physician
November 2024
Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Background: Peripheral nerve stimulation (PNS) has been used for over 50 years to treat chronic pain by delivering electrical pulses through small electrodes placed near targeted peripheral nerves those outside the brain and spinal cord. Early PNS systems often required invasive neurosurgical procedures. However, since 2015, the Food and Drug Administration (FDA) approved percutaneously implanted PNS leads and neurostimulators offering a much less invasive, non-opioid option for managing recalcitrant chronic pain.
View Article and Find Full Text PDFClin Neurophysiol Pract
October 2024
Department of Engineering for Innovation Medicine, University of Verona, Italy.
Myoclonus has multiple clinical manifestations and heterogeneous generators and etiologies, encompassing a spectrum of disorders and even physiological events. This paper, developed from a teaching course conducted by the Neurophysiology Commission of the Italian League against Epilepsy, aims to delineate the main types of myoclonus, identify potential underlying neurological disorders, outline diagnostic procedures, elucidate pathophysiological mechanisms, and discuss appropriate treatments. Neurophysiological techniques play a crucial role in accurately classifying myoclonic phenomena, by means of simple methods such as EEG plus polymyography (EEG + Polymyography), evoked potentials, examination of long-loop reflexes, and often more complex protocols to study intra-cortical inhibition-facilitation In clinical practice, EEG + Polymyography often represents the first step to identify myoclonus, acquire signals for off-line studies and plan the diagnostic work-up.
View Article and Find Full Text PDFVasc Endovascular Surg
November 2024
Department of Surgery, SUNY Upstate Medical University, Syracuse, NY, USA.
Primary aortocaval fistulas (ACF) are a rare complication of abdominal aortic aneurysm (AAA), for which treatment options encompass both endovascular and open surgical intervention. To report a rare presentation of primary aortocaval fistula. Case Report.
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