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Four three-dimensional rare earth metal - organic framework fluorescent sensor for efficient detection of gentamicin sulfate and Fe.
Spectrochim Acta A Mol Biomol Spectrosc
December 2024
College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Changcheng Road 700, Chengyang District, Qingdao 266109, China. Electronic address:
Excessive use of gentamicin sulfate can cause severe nephrotoxicity and ototoxicity, abnormal levels of Fe intake can also cause serious damage to body. Therefore, establishing a fast and accurate detection method for the above-mentioned substances is of great significance. However, traditional detection methods such as high-performance liquid chromatography still have certain problems such as high cost and complex operation.
View Article and Find Full Text PDFA comprehensive review on singlet oxygen generation in nanomaterials and conjugated polymers for photodynamic therapy in the treatment of cancer.
Nanoscale
February 2024
Department of Materials Engineering, Indian Institute of Science, Bangalore, Karnataka - 560012, India.
A key role in lessening humanity's continuous fight against cancer could be played by photodynamic therapy (PDT), a minimally invasive treatment employed in the medical care of a range of benign disorders and malignancies. Cancerous tissue can be effectively removed by using a light source-excited photosensitizer. Singlet oxygen and reactive oxygen species are produced the photosensitizer as a result of this excitation.
View Article and Find Full Text PDFIdentification and optimization of pyridine carboxamide-based scaffold as a drug lead for .
Antimicrob Agents Chemother
February 2024
Translational Health Sciences and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
New drugs with novel mechanisms of action are urgently needed to tackle the issue of drug-resistant tuberculosis. Here, we have performed phenotypic screening using the Pathogen Box library obtained from the Medicines for Malaria Venture against . We have identified a pyridine carboxamide derivative, MMV687254, as a promising hit.
View Article and Find Full Text PDFStructural basis for subversion of host cell actin cytoskeleton during infection.
Sci Adv
December 2023
University Medical Center Hamburg-Eppendorf (UKE), Institute of Structural and Systems Biology, Hamburg, Germany.
Secreted bacterial type III secretion system (T3SS) proteins are essential for successful infection by many human pathogens. Both T3SS translocator SipC and effector SipA are critical for infection by subversion of the host cell cytoskeleton, but the precise molecular interplay between them remains unknown. Here, using cryo-electron microscopy, we show that SipA binds along the F-actin grooves with a unique binding pattern.
View Article and Find Full Text PDFNew 2,4-dihydro-1H-1,2,4-triazole-3-selones and 3,3'-di(4H-1,2,4-triazolyl)diselenides. Synthesis, biological evaluation, and in silico studies as antibacterial and fungicidal agents.
Bioorg Chem
December 2023
R.A. Alekseev State Technical University, Nizhny Novgorod, Minina st. 24, 603950, Russia.
The reaction of aromatic ring-substituted isoselenocyanates with 2-thiopheacetic and 4-pyridinecarboxylic acid hydrazides yielded selenosemicarbazides which were further converted into previously unknown 1,2,4-triazole-3-selones and 3,3'-di(4H-1, 2,4-triazolyl)diselenides. The structures of the obtained compounds were studied by NMR spectroscopy, IR spectroscopy, and high-resolution mass spectroscopy (HR-MS). The bactericidal and fungicidal activity of some obtained compounds was evaluated in molecular modeling studies such as docking and simulation studies.
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