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A potential link has been reported between skin exposure to aromatic amines, such as ortho-toluidine (OT) and 3,3'-dichloro-4,4'-diaminodiphenylmethane (MOCA), and bladder cancer cases observed in Japanese chemical factories. To evaluate this association, we explored the permeability of OT and MOCA through pig skin and investigated the subsequent changes in plasma and urine concentrations in rats following percutaneous exposure. Employing Yucatan micropig skin, we first executed a permeability test by affixing the skin to a diffusion cell and applying 14C-labeled OT or MOCA.

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The evolution and hotspots of radioactive iodine therapy in hyperthyroidism: a bibliometric analysis.

Nucl Med Commun

December 2024

Department of Nuclear Medicine, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang City, Jiangxi Province, China.

Article Synopsis
  • - Hyperthyroidism is a common endocrine disorder that affects metabolic and cardiovascular health, and this study analyzes the evolution of radioactive iodine (RAI) treatment for it through bibliometric analysis of 2904 publications from 1981 to 2023.
  • - The study found a rising trend in annual publications, with the USA leading in contributions and the University of Pisa being particularly prolific; key research areas identified include treatment mechanisms, safety, effectiveness, personalized dosages, and management.
  • - The research emphasizes the need for increased attention and collaboration in the field of RAI treatment for hyperthyroidism, particularly focusing on personalized approaches and the challenges of drug-resistant cases in future studies.
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Background: Since the end of the COVID-19 pandemic, the potential roles of thyroid-inflammatory derangements in driving or being associated with the prognosis of COVID-19 remain controversial. We aimed to clarify the association between COVID-19 infection and thyroid dysfunction, and highlight the impacts of subsequent autoimmune thyroid disease (AITD) on the prognosis of COVID-19.

Methods: The retrospective, multicenter, cohort study enrolled 2,339 participants with COVID-19 from three hospitals located in the north, middle, and south regions of Shaan Xi Province, China, between December 2022 and July 2023.

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Background: The epidemiology and management of thyroid cancer has changed radically in the recent past, with rising international incidence of early-stage papillary thyroid cancer (PTC) in particular. In this paper, we review the epidemiology of thyroid cancer in Ireland.

Methods: A retrospective cohort study of National Cancer Registry of Ireland data, 1994-2019.

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A new 14 MeV neutron spectrometer utilizing the magnetic proton recoil (MPR) technique is under development for the SPARC tokamak. This instrument measures neutrons by converting them into protons, whose momenta are subsequently analyzed using a series of magnets before detection by an array of scintillators known as the hodoscope. In this work, we explore various solutions for the hodoscope detectors through laboratory tests with radioactive sources and simulations.

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