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Biosynthetic small molecule antigens mimics medicated lateral flow immunoassay for mycotoxin Fumonisin B using nanobody fusion proteins.
J Hazard Mater
January 2025
State Key Laboratory of Food Science and Resources, Nanchang University, No. 235 Nanjing East Road, Nanchang 330047, China; Sino-German Joint Research Institute, Nanchang University, No. 235 Nanjing East Road, Nanchang 330047, China; In Vitro Diagnostic Technology Innovation Center for Nanobody, No. 1166 Yiyuan Road, Nanchang, Jiangxi Province 330038, China; International Institute of Food Innovation Co., Ltd., Nanchang University, Luozhu Road, Nanchang 330200, China. Electronic address:
Lateral flow immunoassays (LFAs) are widely used in point-of-care testing (POCT) for detecting small molecules. However, their application is often hindered by the complex synthesis of traditional chemically synthesized antigens. Nanobody-based coating antigen mimics have shown excellent analytical performance in various immunoassay platforms, but their application in LFAs still faces challenges.
View Article and Find Full Text PDFNon-allergic Hypersensitivity Reactions to Immunoglobulin Preparations in Antibody Deficiencies: What Role for Anti-IgA IgG and Complement Activation?
Clin Rev Allergy Immunol
December 2024
Univ. Lille, U1286 - INFINITE - Institute for Translational Research in Inflammation, Lille, France.
Article Synopsis
- * Researchers measured the prevalence of IgG anti-IgA in PID patients compared to healthy controls and found a low percentage of PID patients with these antibodies and hypersensitivity.
- * The study suggests that complement activation might be a more significant factor in hypersensitivity reactions to immunoglobulin preparations, rather than just the presence of IgG anti-IgA.
Advances and challenges in anti-cancer vaccines for multiple myeloma.
Front Immunol
August 2024
Oslo Myeloma Center, Department of Hematology, Oslo University Hospital, Oslo, Norway.
Multiple myeloma (MM) is a hematological cancer marked by plasma cell accumulation in the bone marrow. Despite treatment advancements, MM remains incurable in most patients. MM-associated immune dysregulation fosters disease progression, prompting research into immunotherapy to combat the disease.
View Article and Find Full Text PDFTheories of immune recognition: Is anybody right?
Immunology
October 2024
Laboratório de Pesquisa em Malária, Instituto Oswaldo Cruz and Centro de Pesquisa, Diagnóstico e Treinamento em Malária, Fiocruz, Rio de Janeiro, Rio de Janeiro, Brazil.
The clonal selection theory (CST) is the centrepiece of the current paradigm used to explain immune recognition and memory. Throughout the past decades, the original CST had been expanded and modified to explain new experimental evidences since its original publication by Burnet. This gave origin to new paradigms that govern experimental immunology nowadays, such as the associative recognition of antigen model and the stranger/danger signal model.
View Article and Find Full Text PDFShark anti-idiotypic variable new antigen receptor specific for an alpaca nanobody: Exploration of a nontoxic substitute to ochratoxin A in immunoassay.
J Hazard Mater
September 2024
School of Food Science and Engineering, Hainan University, Haikou 570228, China. Electronic address:
Nontoxic substitutes to mycotoxins can facilitate the development of eco-friendly immunoassays. To explore a novel nontoxic substitute to ochratoxin A (OTA), this study screened shark anti-idiotypic variable new antigen receptors (VNARs) against the alpaca anti-OTA nanobody Nb28 through phage display. After four rounds of biopanning of a naïve VNAR phage display library derived from six adult Chiloscyllium plagiosum sharks, one positive clone, namely, P-3, was validated through a phage enzyme-linked immunosorbent assay (phage ELISA).
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