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Potential anti-schistosomal effect of Daflon, a repurposed drug targeting different stages of Schistosome maturity.
Parasitol Res
November 2024
Department of Medical Parasitology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Despite the long history of experimental trials to combat schistosomiasis, it remains a significant burden due to drug resistance and the effectiveness of the standard treatment only against the mature stage, while skipping other early developmental stages thus leading to severe permanent pathological sequelae. Therefore, repurposing a commonly used well-known safe drug would be a wise alternative. We investigated the potential anti-schistosomal drug activity of Daflon® (DAF) against different schistosomal developmental stages.
View Article and Find Full Text PDFDevelopment of Hot Melt Extruded Co-Formulated Artesunate and Amodiaquine- Soluplus Solid Dispersion System in Fixed-Dose Form: Amorphous State Characterization and Pharmacokinetic Evaluation.
Curr Drug Metab
December 2024
Department of Pharmaceutics and Industrial Pharmacy, College of Pharmacy, Taif University, Taif, 21944, Saudi Arabia.
Introduction: This study aims to develop co-amorphous Solid Dispersion (SD) system containing antimalarials Artesunate (ARS) and Amodiaquine (AMQ) to improve its oral bioavailability employing the Hot Melt Extrusion (HME) technique. Soluplus was selected as a polymeric excipient, whereas Lutrol F127, Lutrol F68, TPGS, and PEG400 as surfactants were incorporated along with Soluplus to enhance extrudability, improve hydrophilicity, and improve the blend viscosity during HME. Soluplus with surfactant combination successfully stabilizes both drugs during extrusion by generating SD because of its lower glass transition temperature (Tg) and viscoelastic behavior.
View Article and Find Full Text PDFIn vivo antischistosomal efficacy of Porcelia ponderosa γ-lactones.
Phytomedicine
December 2024
Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Santo André, SP, 09210-180, Brazil. Electronic address:
Background: Schistosomiasis, caused by the parasitic blood fluke Schistosoma mansoni, is a significant global health concern, particularly in tropical and subtropical regions. The available chemotherapeutic drug is restricted to praziquantel with present problems related to efficacy, toxicity and resistance, justifying the search for new drugs. Different natural products, including γ-lactones, have demonstrated anthelmintic activity.
View Article and Find Full Text PDFQuality assessment of common anti-malarial medicines marketed in Gambella, National Regional State, South Western-Ethiopia.
Malar J
September 2024
Department of Pharmaceutical Chemistry and Pharmacognosy, School of Pharmacy, College of Health Sciences, Addis Ababa University, P.O Box.1176, Addis Ababa, Ethiopia.
Background: Over the past years, there has been a growing concern that a considerable amount of anti-malarial supply in the underdeveloped world particularly in the private sector, is of poor quality. The World Health Organization (WHO) has received about 1500 reports that mentions instances of substandard and falsified products since 2013. The majority of the reports concerned antibiotics and anti-malarials.
View Article and Find Full Text PDFSchistosomicidal effects of histone acetyltransferase inhibitors against Schistosoma japonicum juveniles and adult worms in vitro.
PLoS Negl Trop Dis
August 2024
Department of Parasitology, School of Basic Medical Sciences, Suzhou Medical College of Soochow University, Suzhou City, P. R. China.
Article Synopsis
- Schistosomiasis, affecting over 250 million globally, relies heavily on praziquantel (PZQ) for treatment, but this method is unsustainable, leading to a push for new drug candidates.
- A study identified curcumin as the most effective inhibitor against Schistosoma japonicum, with notable impacts on both juvenile and adult parasites, while two other inhibitors had limited effects.
- Both curcumin and a PZQ derivative (DW-3-15) significantly reduced the expression of a key protein (SjHAT), suggesting that SjHAT could be a promising target for innovative antischistosomal treatments.
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