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Case Report of an Urgent Determination of Malignant Hyperthermia Status of a 24-Week Pregnant Patient Requiring Intrauterine Fetal Surgery.
A A Pract
December 2024
From the Department of Anesthesiology, Uniformed Services University, Bethesda, Maryland.
Malignant hyperthermia (MH) is a potentially fatal disorder triggered by volatile anesthetics or succinylcholine, inducing a hypermetabolic crisis in susceptible patients. The caffeine-halothane contracture test (CHCT) remains a gold standard for MH detection. The authors describe a pregnant patient with a history of exertional rhabdomyolysis, who required urgent MH screening for administration of MH-triggering anesthetics.
View Article and Find Full Text PDFAnalysis of cardiohemodynamic and electrophysiological effects of morphine along with its toxicokinetic profile using the halothane-anesthetized dogs.
J Toxicol Sci
June 2024
Department of Pharmacology, Faculty of Medicine, Toho University.
Although morphine has been used for treatment-resistant dyspnea in end-stage heart failure patients, information on its cardiovascular safety profile remains limited. Morphine was intravenously administered to halothane-anesthetized dogs (n=4) in doses of 0.1, 1 and 10 mg/kg/10 min with 20 min of observation period.
View Article and Find Full Text PDFHepatoprotective effect of methanol fruit extract of L in highly active antiretroviral therapy-induced toxicity in Wistar rats.
Drug Chem Toxicol
March 2024
Department of Science Technical and Vocational Education, Makerere University, Kampala, Uganda.
Article Synopsis
- Prolonged use of Highly Active Antiretroviral Therapy (HAART) can cause liver toxicity, with limited treatment options for hepatic cell regeneration.
- A study assessed the protective effects of Methanol fruit extract (MFEPG) on rats undergoing HAART, revealing that MFEPG helped restore normal liver function and reduced oxidative damage indicators.
- The findings suggest that MFEPG has antioxidant properties capable of mitigating HAART-induced liver injury, but further research is necessary to confirm its safety and efficacy.
Methanol Crude Peel Extract of Prevents Oxidative Damage in Kidneys of Rats Exposed to Highly Active Antiretroviral Therapy.
J Exp Pharmacol
January 2024
Department of Biochemistry, Faculty of Biomedical Sciences, Kampala International University-Western Campus, Bushenyi, Uganda.
Background: Highly Active Antiretroviral Therapy (HAART) has been linked to oxidative damage to kidney cells leading to renal disease in people living with HIV/AIDS on HAART treatment. The toxic effects of HAART affect the patients' quality of life leading to poor adherence to their regimen. Therefore, the purpose of this study was to investigate the nephron-protective activity of methanol crude peel extract of (MPEPG) in HAART-administered Wistar rats.
View Article and Find Full Text PDFKidney cell DNA damage caused by combined exposure to volatile anaesthetics and 1 Gy or 2 Gy radiotherapy dose .
Arh Hig Rada Toksikol
April 2022
Institute for Medical Research and Occupational Health, Mutagenesis Unit, Zagreb, Croatia.
Patient immobilisation with volatile anaesthetics (VA) during radiotherapy is sometimes unavoidable. Although it is known that both VAs and ionising radiation can have nephrotoxic effects, there are no studies of their combined effects on DNA damage. The aim of this study was to address this gap by investigating whether 48 groups of healthy Swiss albino mice (totalling 240) would differ in kidney cell DNA damage response (alkaline comet assay) to isoflurane, sevoflurane, or halothane anaesthesia and exposure to 1 Gy or 2 Gy of ionising radiation.
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