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Cytoreduction and Hyperthermic Intrathoracic Chemotherapy for Metastatic Pseudomyxoma Peritonei.
Ann Thorac Surg Short Rep
September 2024
Division of Thoracic Surgery, Mayo Clinic, Rochester, Minnesota.
Pleural extension of pseudomyxoma peritonei is rare, and treatment demands multidisciplinary care. Perioperative management during cytoreductive surgery and hyperthermic intrathoracic chemotherapy challenges anesthesiology and surgical teams in unique ways. Hemodynamic, arrhythmogenic, ventilatory, fluid balance, acid-base, and nephroprotection issues are important considerations.
View Article and Find Full Text PDFComplexities, Benefits, Risks, and Clinical Implications of Sodium Bicarbonate Administration in Critically Ill Patients: A State-of-the-Art Review.
J Clin Med
December 2024
Emergency Medicine, Freeman Health System, Joplin, MO 64804, USA.
Sodium bicarbonate has been used in the treatment of different pathologies, such as hyperkalemia, cardiac arrest, tricyclic antidepressant toxicity, aspirin toxicity, acute acidosis, lactic acidosis, diabetic ketoacidosis, rhabdomyolysis, and adrenergic receptors' resistance to catecholamine in patients with shock. An ongoing debate about bicarbonate's efficacy and potential harm has been raised for decades because of the lack of evidence supporting its potential efficacy. Despite the guidelines' restrictions, sodium bicarbonate has been overused in clinical practice.
View Article and Find Full Text PDFMetabolic Effects of Sodium Thiosulfate During Resuscitation from Trauma and Hemorrhage in Cigarette-Smoke-Exposed Cystathionine-γ-Lyase Knockout Mice.
Biomedicines
November 2024
Institute for Anesthesiological Pathophysiology and Process Engineering, Ulm University, 89081 Ulm, Germany.
Background: Acute and chronic pre-traumatic cigarette smoke exposure increases morbidity and mortality after trauma and hemorrhage. In mice with a genetic deletion of the HS-producing enzyme cystathione-γ-lyase (CSE), providing exogenous HS using sodium thiosulfate (NaSO) improved organ function after chest trauma and hemorrhagic shock. Therefore, we evaluated the effect of NaSO during resuscitation from blunt chest trauma and hemorrhagic shock on CSE mice with pre-traumatic cigarette smoke (CS) exposure.
View Article and Find Full Text PDFComprehensive echocardiographic and biomarker assessment of patients with diabetic ketoacidosis.
Cardiovasc Diabetol
October 2024
Cardiology Service, Hospital Universitario "Dr. José E. González", Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico.
Background: Systemic stress, inflammation, and hydroelectrolytic and acid‒base abnormalities observed during diabetic ketoacidosis (DKA) can cause changes in the heart and even induce cardiovascular damage. We aimed to evaluate the structure and function of the heart during and after a DKA episode via echocardiography and biomarker assessment.
Methods: We performed a transthoracic echocardiogram (TTE) in subjects with an episode of DKA in the first 4-6 h of treatment.
Comparative Evaluation of 0.9% Normal Saline Versus Acetate-Gluconate-Based Balanced Solution on Acid-Base Status and Postoperative Liver Function in Donor Hepatectomy Patients.
Cureus
September 2024
Department of Anesthesiology, Pain and Perioperative Medicine, Sir Ganga Ram Hospital, New Delhi, IND.
Article Synopsis
- The study examines the effects of 0.9% normal saline versus PlasmaLyte A® on acid-base status and liver function in 40 healthy adults undergoing live donor liver transplantation.
- Results indicated that PlasmaLyte A® maintained better acid-base balance, with higher pH and bicarbonate levels, while normal saline led to a significant drop in bicarbonate levels during surgery.
- Although no major differences in postoperative liver function were observed between the two groups, a trend suggested that PlasmaLyte A® might lead to better outcomes.
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