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The value of blood lactate and lactate clearance rate in evaluating the prognosis of athletes with heat illness of varying degrees after high-intensity exercise.
BMC Sports Sci Med Rehabil
January 2025
Department of Pharmacy, The 969 th Hospital of P.L.A, Hohhot, 010051, China.
Background: Heat stroke, a severe heat illness with organ damage, is a major cause of cause irreparable organ damage and higher death rates among military persons and athletes.
Objectives: To study the changes in blood lactate (Lac) levels and lactate clearance rate (LCR) in athletes with heat illness of varying degrees after high-intensity exercise and to evaluate their prognostic value.
Material And Methods: In present study, acute care unit admitted 36 heat sickness patients following high-intensity exercise from December 2019 to July 2024, with comprehensive medical records, for retrospective study.
DNA damage triggers the death of green sea turtle-derived cells at high temperature.
Comp Biochem Physiol C Toxicol Pharmacol
January 2025
Graduate School of Science and Engineering, Iwate University, 4-3-5, Ueda, Morioka-city 020-8551, Japan.
As temperatures rise due to increasingly severe global warming, the effect of high temperatures on wildlife, including green sea turtles, is one of the issues that must be addressed to ensure the conservation of biodiversity. In the current study, we found that green sea turtle cell death due to apoptosis occurred at 37 °C, which suppressed cell proliferation. We also found that high temperature-induced heat stress led to the accumulation of DNA damage in green sea turtle cells.
View Article and Find Full Text PDFN6-methyladenosine modification of host Hsc70 attenuates nucleopolyhedrovirus infection in the lepidopteran model insect Bombyx mori.
Int J Biol Macromol
January 2025
Integrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City & Southwest University, Biological Science Research Center, Southwest University, Chongqing, China; Key Laboratory for Germplasm Creation in Upper Reaches of the Yangtze River, Ministry of Agriculture and Rural Affairs, Chongqing, China. Electronic address:
N6-methyladenosine (m6A) is the most prevalent internal modification on mRNA and plays critical roles in various biological processes including virus infection. It has been shown that m6A methylation is able to regulate virus proliferation and host innate immunity in mammals and plants, however, this antiviral defense in insects is largely unknown. Here we investigated function of m6A and its associated methyltransferases in nucleopolyhedrovirus (BmNPV) infection in silkworm.
View Article and Find Full Text PDFA pilot observational study of the association of 24-hour mortality with the subjective assessment of the forearm skin temperature and moisture compared to other bedside indicators of illness severity.
Resusc Plus
January 2025
School of Clinical and Biomedical Sciences, University of Bolton, United Kingdom.
Background: Although the association of peripheral skin temperature with infection, serious illness and death have been recognised for centuries, few studies have explicitly compared this finding with other bedside indicators of illness severity. This study compared subjectively assessed dorsal forearm skin temperature and moisture with other indicators of illness severity.
Methods: Non-interventional observational study of acutely ill medical patients admitted to a low-resource Ugandan hospital, which examined the association of subjectively assessed dorsal forearm skin temperature and other bedside findings with death within 24 h.
The pathogenesis and management of heatstroke and heatstroke-induced lung injury.
Burns Trauma
January 2025
Treatment Center for Traumatic Injuries, The Third Affiliated Hospital, Southern Medical University, No. 183, Zhongshan Avenue West, Tianhe District, Guangzhou, 510063, Guangdong, China.
In the past two decades, record-breaking heat waves have caused an increasing number of heat-related deaths, including heatstroke, globally. Heatstroke is a life-threatening systemic condition characterized by a core body temperature >40°C and the subsequent development of multiple organ dysfunction syndrome. Lung injury is a well-documented complication of heatstroke and is usually the secondary cause of patient death.
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