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Causal association between pregnancy disorders and neonatal jaundice: a two-sample Mendelian randomization study.
Transl Pediatr
December 2024
Department of Neonatology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Background: Some studies have suggested that complications during pregnancy, such as preeclampsia, leiomyoma during pregnancy, oxytocin induction, and mode of delivery, may be risk factors for neonatal jaundice. Herein, we applied Mendelian randomization (MR) analysis to investigate a causal association between pregnancy disorders and neonatal jaundice.
Methods: Data related to neonatal jaundice and pregnancy disorders (including pre-eclampsia or eclampsia, gestational diabetes, and gestational edema) were sourced from the FinnGen Consortium and Integrated Epidemiology Unit (IEU) databases.
Exploring the gut-inflammation connection: A Mendelian randomization study on gut microbiota, inflammatory factors, and uterine fibroids risk.
Medicine (Baltimore)
November 2024
Department of Cardiology, Center Hospital of Shandong First Medical University, Jinan, China.
This study employs Mendelian randomization (MR) approach to investigate the potential causal association between genetic variants associated with gut microbiota, inflammatory factors, and the risk of uterine fibroids development. We extracted data on 211 types of gut microbiota, 91 inflammatory factors, and uterine fibroids occurrence from genome-wide association studies and applied the inverse-variance weighted (IVW) method for analysis. To further assess the robustness of our MR analysis, we conducted sensitivity tests including Cochrane's Q test, the MR-Egger intercept test, the MR-PRESSO global test, and a leave-one-out analysis.
View Article and Find Full Text PDFUterine leiomyoma causes an increase in systolic blood pressure: a two-sample Mendelian randomization study.
Front Endocrinol (Lausanne)
May 2024
Disease Prevention Center, The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
Objectives: Hypertension and hypertensive disorders of pregnancy (HDP) are common diseases in women at different stages, which affect women's physical and mental health, and the impact of the latter on the offspring cannot not be ignored. Observational studies have investigated the correlation between uterine leiomyoma (UL) and the above conditions, but the relationship remains unclear. In this study, we employed two-sample Mendelian randomization (MR) analysis to assess the association between UL and hypertension, HDP, as well as blood pressure.
View Article and Find Full Text PDFI saw the Venetian blind sign.
Clin Imaging
February 2024
Department of Radiology, University of Missouri, Columbia, MO, United States. Electronic address:
The Venetian blind sign is a radiologic sign seen on pelvic ultrasound. It is classically associated with adenomyosis and, less commonly, uterine fibroids. It appears as alternating vertical stripes of hyperechoic and hypoechoic bands, resembling the horizontal slatted window blinds for which it is named.
View Article and Find Full Text PDFPhenome-wide Mendelian randomization study of plasma triglyceride levels and 2600 disease traits.
Elife
March 2023
Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, United States.
Background: Causality between plasma triglyceride (TG) levels and atherosclerotic cardiovascular disease (ASCVD) risk remains controversial despite more than four decades of study and two recent landmark trials, STRENGTH, and REDUCE-IT. Further unclear is the association between TG levels and non-atherosclerotic diseases across organ systems.
Methods: Here, we conducted a phenome-wide, two-sample Mendelian randomization (MR) analysis using inverse-variance weighted (IVW) regression to systematically infer the causal effects of plasma TG levels on 2600 disease traits in the European ancestry population of UK Biobank.
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