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Chem Biodivers
January 2025
St Xavier's College, Kolkata, Department of Chemistry, 30, Mother teresa Sarani, Kol-16, 700016, Kolkata, INDIA.
Amino-quinolines are potential candidates that may provide some insight into the current chemotherapeutic research due to their demonstrated anti-cancer activity. This led us to synthesize and explore a new amino-azo-quinoline ligand H2L 1 and its square planar nickel(II) complexes [Ni(HL)(OAc)], 2 and [Ni(HL)Cl], 3 and the structures were determined by SCXRD. Theoretical investigation of redox orbitals of the complexes discloses that the reduction process is due to ligand reduction whereas both metal and ligand are contributing towards oxidation.
View Article and Find Full Text PDFCancer Epidemiol Biomarkers Prev
January 2025
University of Kentucky, Lexington, KY, United States.
Background: Kentucky is within the top five leading states for breast mortality nationwide. This study investigates the association between neighborhood socioeconomic disadvantage and breast cancer outcomes, including surgical treatment, radiation therapy, chemotherapy, and survival, and how associations vary by race and ethnicity in Kentucky.
Methods: We conducted a retrospective cohort analysis using data from the Kentucky Cancer Registry (KCR) for breast cancer patients diagnosed between 2010 and 2017, with follow-up through December 31, 2022.
Mol Cancer Res
January 2025
Fox Chase Cancer Center, Philadelphia, PA, United States.
Breast cancers of the IntClust-2 type, characterized by amplification of a small portion of chromosome 11, have a median survival of only five years. Several cancer-relevant genes occupy this portion of chromosome 11, and it is thought that overexpression of a combination of driver genes in this region is responsible for the poor outcome of women in this group. In this study we used a gene editing method to knock out, one by one, each of 198 genes that are located within the amplified region of chromosome 11 and determined how much each of these genes contributed to the survival of breast cancer cells.
View Article and Find Full Text PDFArch Environ Occup Health
January 2025
Department of Physiotherapy, School of Allied Health Sciences, Galgotias University, Greater Noida, Uttar Pradesh, India.
During the COVID-19 pandemic, the need for computer-users to work-from-home (WFH) has increased world-wide. This study aims to explore how the COVID-19 lockdown has affected pain in the lower-back of adult computer professionals. Individuals aged 20-55, both male and female, meeting inclusion criteria (computer/laptop WFH, worked more than an hour on a computer/laptop) were invited to participate voluntarily after providing informed consent.
View Article and Find Full Text PDFJ Evid Based Soc Work (2019)
January 2025
Department of Criminology and Police Science, University of Chittagong, Chattogram, Bangladesh.
Purpose: Human trafficking survivors' successful social reintegration is of paramount importance. However, survivors found it difficult to build their lives in Bangladesh upon return. The specific challenges encountered by Bangladeshi trafficking survivors remain underexplored, particularly regarding individual, socio-cultural, and systematic factors.
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