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Deconvoluting thermomechanical effects in X-ray diffraction data using machine learning.
Acta Crystallogr A Found Adv
March 2025
Pennsylvania State University, University Park, PA 16802, USA.
X-ray diffraction is ideal for probing the sub-surface state during complex or rapid thermomechanical loading of crystalline materials. However, challenges arise as the size of diffraction volumes increases due to spatial broadening and because of the inability to deconvolute the effects of different lattice deformation mechanisms. Here, we present a novel approach that uses combinations of physics-based modeling and machine learning to deconvolve thermal and mechanical elastic strains for diffraction data analysis.
View Article and Find Full Text PDFPAX6 enhances Nanog expression by inhibiting NOTCH signaling to promote malignant properties in small cell lung cancer cells.
Heliyon
January 2025
Department of Medical Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Small cell lung cancer (SCLC) is a highly aggressive form of lung cancer. The aberrant regulation of Paired box 6 (PAX6) expression has been proposed to play an important oncogenic role in several cancer types. Nevertheless, there is limited knowledge regarding its function in SCLC.
View Article and Find Full Text PDFExamining Ethiopia's live animal and meat value chain.
Heliyon
January 2025
Department of Animal Science, Wolaita Sodo University, P.O.BOX. 138, Wolaita Sodo, Ethiopia.
This review examines the efficiency of live animal and meat value chain from producers to consumers in Ethiopia. Ethiopia has a large livestock population, but the marketing system for live animals and meat remains underdeveloped. Several challenges hinder efficient transactions, including poor infrastructure, illegal cross-border trade, lack of market information, traditional production methods, and absence of grading systems.
View Article and Find Full Text PDFHealthcare exceptionalism: should healthcare be treated differently when it comes to reducing greenhouse gas emissions?
Med Health Care Philos
January 2025
Faculty of Health and Medicine, Health Innovation One, Sir John Fisher Drive, Lancaster University, Lancaster, LA1 4AT, England.
Healthcare systems produce significant greenhouse gas emissions, raising an important question: should healthcare be treated like any other polluter when it comes to reducing its emissions, or is healthcare special because of its essential societal role? On one hand, reducing emissions is critical to combat climate change. On the other, healthcare depends on emissions to deliver vital services. The resulting tension surrounds an idea of healthcare exceptionalism and leads to the question I consider in this paper: to what extent (if any) should the valuable goals of healthcare form an exception to the burdens of reducing greenhouse gas emissions? The goals of this paper are twofold.
View Article and Find Full Text PDFOmics-Based Comparison of Fungal Virulence Genes, Biosynthetic Gene Clusters, and Small Molecules in and .
J Fungi (Basel)
December 2024
Food Quality Laboratory, U.S. Department of Agriculture, Agricultural Research Service, Beltsville Agricultural Research Center, Beltsville, MD 20705, USA.
is a ubiquitous pathogenic fungus that causes blue mold decay of apple fruit postharvest, and another member of the genus, , is a well-studied saprophyte valued for antibiotic and small molecule production. While these two fungi have been investigated individually, a recent discovery revealed that can block mediated decay of apple fruit. To shed light on this observation, we conducted a comparative genomic, transcriptomic, and metabolomic study of two (404 and 413) and two (Pe21 and R19) isolates.
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