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| http://dx.doi.org/10.1136/gut.10.3.198 | DOI Listing |
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The fate of the rectum in ulcerative colitis at index surgery and beyond-a contemporary cohort.
Int J Colorectal Dis
January 2025
Department of Colorectal Surgery, Beaumont Hospital, Dublin 9, Ireland.
Purpose: Proctectomy is frequently deferred at index colectomy for ulcerative colitis due to acuity or immunosuppressive treatments. The retained rectum remains symptomatic in over 50% with associated cancer risk. Management options include index or delayed proctectomy with or without restoration of continuity or surveillance.
View Article and Find Full Text PDFMetabolomics Analysis for Unveiling the Toxicological Mechanism of Silver Nanoparticles Using an Gastrointestinal Digestion Model.
ACS Nanosci Au
October 2024
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
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- * A simulated digestion model was used to study how the physicochemical properties of AgNPs change during digestion and to explore their toxic effects on intestinal cells through metabolomics analysis.
- * Results indicate that conditions in the GIT, including acidity and the presence of digestive enzymes, can enhance Ag uptake by gut cells, leading to oxidative stress and potential cell damage, with implications for understanding the health risks associated with AgNPs.
CT45A1-mediated MLC2 (MYL9) phosphorylation promotes natural killer cell resistance and outer cell fate in a cell-in-cell structure, potentiating the progression of microsatellite instability-high colorectal cancer.
Mol Oncol
September 2024
Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Patients with microsatellite instability-high (MSI-H) colorectal cancer (CRC) have high tumor mutation burden and tumor immunogenicity, exhibiting a higher response rate to immunotherapy and better survival. However, a portion of MSI-H CRC patients still experience adverse disease outcomes. We aimed to identify the tumor-autonomous regulators determining these heterogeneous clinical outcomes.
View Article and Find Full Text PDFFate of ileorectal anastomosis for treating Crohn's disease in the era of biologics: Results from a French retrospective multicentre cohort study.
Colorectal Dis
November 2024
Department of Digestive Surgery and Transplantation, University Hospital of Lille Nord de France, Lille, France.
Article Synopsis
- The study aimed to understand the recurrence rates of surgical issues in patients with Crohn's disease who underwent ileorectal anastomosis during the biologics era, noting that previous studies lacked data from this period.
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The cloaca is a transient structure that forms in the terminal hindgut giving rise to the rectum dorsally and the urogenital sinus ventrally. Similarly, human hindgut cultures derived from human pluripotent stem cells generate human colonic organoids (HCOs) which also contain co-developing urothelial tissue. In this study, our goal was to identify pathways involved in cloacal patterning and apply this to human hindgut cultures.
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