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SUMOylation of Warts kinase promotes neural stem cell reactivation.
Nat Commun
October 2024
Neuroscience and Behavioral Disorders Programme, Duke-NUS Medical School, Singapore, Singapore.
A delicate balance between neural stem cell (NSC) quiescence and proliferation is important for adult neurogenesis and homeostasis. Small ubiquitin-related modifier (SUMO)-dependent post-translational modifications cause rapid and reversible changes in protein functions. However, the role of the SUMO pathway during NSC reactivation and brain development is not established.
View Article and Find Full Text PDFFLT3L governs the development of partially overlapping hematopoietic lineages in humans and mice.
Cell
May 2024
Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Necker Hospital for Sick Children, Paris, France; Paris Cité University, Imagine Institute, Paris, France; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA. Electronic address:
FMS-related tyrosine kinase 3 ligand (FLT3L), encoded by FLT3LG, is a hematopoietic factor essential for the development of natural killer (NK) cells, B cells, and dendritic cells (DCs) in mice. We describe three humans homozygous for a loss-of-function FLT3LG variant with a history of various recurrent infections, including severe cutaneous warts. The patients' bone marrow (BM) was hypoplastic, with low levels of hematopoietic progenitors, particularly myeloid and B cell precursors.
View Article and Find Full Text PDFTumor of follicular infundibulum - reappraisal in a series of 28 patients with critical review of the literature.
J Dtsch Dermatol Ges
February 2024
Private Dermatohistopathological Laboratory Zelger, Innsbruck, Austria.
Article Synopsis
- Tumor of follicular infundibulum (TFI) is a controversial neoplasm that can occur alone or with other skin lesions, leading to varied definitions in histopathology.
- A study analyzed 28 patients with TFI, correlating their cases with existing literature, revealing a mix of patients with various skin conditions.
- The study concludes that TFI represents an epithelial growth pattern that may arise from different skin conditions and is best classified under seborrheic keratoses.
Human papillomavirus in cancer: Infection, disease transmission, and progress in vaccines.
J Infect Public Health
April 2023
Department of Biology, Faculty of Sciences, University of Tabuk, Tabuk, Kingdom of Saudi Arabia; Genome and Biotechnology Unit, Faculty of Sciences, University of Tabuk, Tabuk, Kingdom of Saudi Arabia. Electronic address:
Human papillomaviruses (HPVs) infect epithelial cells of human beings, and their replication cycle is associated with epithelial differentiation. More than 200 genotypes of HPVs were identified, and each of these HPVs shows distinct specificity for tissues and infection. HPV infection was involved in the development of lesions on the feet, genital warts and hands.
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