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Mitochondrial Mayhem: How cigarette smoke induces placental dysfunction through MMS19 degradation.
Ecotoxicol Environ Saf
January 2025
Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang 110004, PR China. Electronic address:
Cigarette smoke (CS) has detrimental effects on placental growth and embryo development, but the underlying mechanisms remain unclear. This study aims to investigate the impact of CS on trophoblast cell proliferation and regulated cell death (RCD) by examining its interference with iron-sulfur cluster (ISC) proteins and the CIA pathway. Exposure to CS disrupted the cytosolic ISC assembly (CIA) pathway, downregulated ISC proteins, and decreased ISC maturation in the placenta of rats exposed to passive smoking.
View Article and Find Full Text PDFEffect of Hot Water Bottle and Cloth Blanket on Rectal Temperature During Magnetic Resonance Imaging of the Head in Cats Under General Anesthesia.
Life (Basel)
December 2024
Faculty of Veterinary Medicine, University of Agronomic Sciences and Veterinary Medicine of Bucharest, 011464 Bucharest, Romania.
Maintaining an animal's body temperature during magnetic resonance imaging (MRI) poses great challenges, as many temperature measuring devices and warming systems are incompatible with the MRI machine. The aim of this study was to examine body temperature changes and evaluate the impact of using a hot water bottle and a cloth blanket on rectal temperature during magnetic resonance imaging in cats. We included in this study 30 cats from different breeds that underwent magnetic resonance imaging for 60 min that were randomly divided into a passively insulated group (G1) covered with a blanket ( = 15) and a positively heated group (G2) using a silicone hot water bottle under the abdomen and the same cloth blanket over the cat ( = 15).
View Article and Find Full Text PDFRAP-2 and CNH-MAP4 Kinase MIG-15 confer resistance in bystander epithelium to cell-fate transformation by excess Ras or Notch activity.
Proc Natl Acad Sci U S A
January 2025
Department of Translational Medical Sciences, School of Medicine, Texas A&M Health Science Center, Texas A&M University, Houston, TX 77030.
Induction of cell fates by growth factors impacts many facets of developmental biology and disease. LIN-3/EGF induces the equipotent vulval precursor cells (VPCs) in to assume the 3˚-3˚-2˚-1˚-2˚-3˚ pattern of cell fates. 1˚ and 2˚ cells become specialized epithelia and undergo stereotyped series of cell divisions to form the vulva.
View Article and Find Full Text PDFCocktail strategy-based nanomedicine: A synergistic cascade of starvation, NIR-II photothermal, and gas therapy for enhanced tumor immunotherapy.
Acta Biomater
December 2024
Guangdong Provincial Key Laboratory of New Drug Screening, Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, Guangdong-Hong Kong-Macao Joint Laboratory for New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China. Electronic address:
Immunotherapy has emerged as a highly promising strategy in the realm of cancer treatment, wherein immunogenic cell death (ICD) is considered a potential trigger for anti-tumor immunity by inducing adaptive immunity to dying cell antigens. This process is often accompanied by the exposure, active secretion, or passive release of a large number of damage-associated molecular patterns (DAMPs), which activate dendritic cells (DCs) and enhance their antigen-presenting capacity. Subsequently, it promotes the recruitment and activation of cytotoxic T lymphocytes, ultimately leading to tumor growth inhibition.
View Article and Find Full Text PDFSelf-management behavior preferences and influencing factors in Chinese patients with recurrent gout: A qualitative study.
Int J Nurs Sci
November 2024
Public Service Department, The First Hospital of China Medical University, Shenyang, China.
Objectives: This study aimed to explore the preferences and influencing factors of self-management behaviors in patients with recurrent gout and provide a theoretical basis for developing targeted strategies to improve self-management preferences.
Methods: A total of 10 patients with recurrent gout were recruited from the gout specialist outpatient clinic at a tertiary hospital in Shenyang, Liaoning Province, China. Semi-structured interviews were conducted with these patients, and the Kawakita Jiro (KJ) method was used to analyze the interview data.
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