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Anticancer potential of nerolidol on acute lymphoblastic leukemia cells through the interactions with the NF-κB/STAT-3 and PI3K/Akt signaling pathways.
Adv Clin Exp Med
January 2025
Department of Hematology, Rheumatology and Immunology, The First People's Hospital of Xianyang, China.
Background: Leukemia may form at any age, from newborns to the elderly, and accounts for considerable mortality worldwide.
Objectives: Nerolidol (NRD) is isolated from the aromatic florae oils and was found to have anticancer activities. However, the role of NRD in antiproliferative and apoptosis actions in acute lymphoblastic leukemia (ALL) is unclear.
Microwave-Assisted Buchwald-Hartwig Double Amination: A Rapid and Promising Approach for the Synthesis of TADF Compounds.
ACS Omega
December 2024
Department of Chemistry, Faculty of Science, Universiti Malaya, 50603 Kuala Lumpur, Malaysia.
We herein report a microwave-assisted Buchwald-Hartwig double amination reaction to synthesize potential thermally activated delayed fluorescence compounds, forming C(sp)-N bonds between donor and acceptor units. Our approach reduces reaction times from 24 h to 10-30 min and achieves moderate to excellent yields, outperforming conventional heating methods. The method is compatible with various aryl bromides and secondary amines, including phenoxazine, phenothiazine, acridine, and carbazole.
View Article and Find Full Text PDFEvaluating binding behavior of quercetin to human serum albumin and calf thymus DNA: Insights from molecular dynamics, spectroscopy, and apoptotic pathway regulation.
Spectrochim Acta A Mol Biomol Spectrosc
December 2024
Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran. Electronic address:
In this work, we sought to apprehend quercetin binding affinity and its interaction behavior in complex with human serum albumin (HSA) and calf thymus DNA (ctDNA) through multi spectroscopy and molecular dynamics and also evaluated its effects on colorectal cancer. The binding constants of ctDNA-quercetin and HSA-quercetin complexes at 298 K, which were calculated to be (2.67 ± 0.
View Article and Find Full Text PDFTailoring DNA Surface Interactions on Single-Layer Graphene: Comparative Analysis of Pyrene, Acridine, and Fluorenyl Methyl Linkers.
Langmuir
January 2025
International Iberian Nanotechnology Laboratory, 4715-330 Braga, Portugal.
This study investigates the effect of different linkers and solvents on the immobilization of DNA probes on graphene surfaces, which are crucial for developing high-performance biosensors. Quartz crystal microbalance with dissipation (QCM-D) measurements were used to characterize in situ and real-time the immobilization of ssDNA and hybridization efficiency on model graphene surfaces. The DNA probes immobilization kinetics and thermodynamics were systematically investigated for all the pairings between three bifunctional linkers─1-pyrenebutyric acid succinimidyl ester (PBSE), Fluorenylmethylsuccinimidyl carbonate (FSC), and Acridine Orange (AO) succinimidyl ester─and three organic solvents (DMF, DMSO, and 10% DMF/ethanol).
View Article and Find Full Text PDFAcridine orange fluorescence in chromosome cytochemistry: Molecular modeling rationale for understanding the differential fluorescence on double- and single-stranded nucleic acids.
Acta Histochem
December 2024
Instituto de Ciencias Ambientales y Salud (ICAS), Fundación Pro Salud y Medio Ambiente (PROSAMA), Paysandú 752, Buenos Aires CP1405, Argentina; Centro Integrativo de Biología y Química Aplicada (CIBQA), Universidad Bernardo O'Higgins, General Gana 1702, Santiago 8370854, Chile. Electronic address:
Many fluorophores display interesting features that make them useful biological labels and dyes, particularly in Cell Biology and Cytogenetics. Changes in the absorption-emission spectra (ortho- and metachromasia) are accounted among them. Acridine orange (AO) is one of such fluorochromes with an exemplary orthochromatic vs.
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