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Transethosomes: A Comprehensive Review of Ultra-Deformable Vesicular Systems for Enhanced Transdermal Drug Delivery.
AAPS PharmSciTech
January 2025
Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.
The transdermal route is one of the effective routes for delivering drugs. It also overcomes many limitations associated with oral delivery. One of the limitations of this route is the drug's poor skin permeability-stratum corneum, the skin's outermost layer that also acts as a barrier for the drug to penetrate.
View Article and Find Full Text PDFSynergistic utilization of glucose and xylose for the myo-inositol biosynthesis in recombinant BL21.
Prep Biochem Biotechnol
January 2025
College of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, Zhejiang Province, People's Republic of China.
Myo-inositol is an active sugar alcohol which has important physiological functions. In this study, an engineered strain that could simultaneously utilize glucose and xylose to produce myo-inositol was constructed, and its fermentation performance was determined. Firstly, the gene was deleted to make BL21 capable of utilizing glucose and xylose simultaneously as mixed carbon source.
View Article and Find Full Text PDFStructural Transformation and Degradation of Cu Oxide Nanocatalysts during Electrochemical CO Reduction.
J Am Chem Soc
January 2025
Liquid Sunlight Alliance, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, California 94720, United States.
The electrochemical CO reduction reaction (CORR) holds enormous potential as a carbon-neutral route to the sustainable production of fuels and platform chemicals. The durability for long-term operation is currently inadequate for commercialization, however, and the underlying deactivation process remains elusive. A fundamental understanding of the degradation mechanism of electrocatalysts, which can dictate the overall device performance, is needed.
View Article and Find Full Text PDFRadiation dosimetry performance appraisal of the optimal concentration of nitro blue tetrazolium dye in PVA composite film at low X-ray doses.
Heliyon
January 2025
Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah 51452, Saudi Arabia.
Purpose: Due to the extensive use of radiation in various fields, such as food safety, sterilizing surgical materials, and medical diagnostics, it is essential to minimize radiation exposure for both patients and healthcare professionals, even at low doses. To meet this requirement, a composite film has been developed using polyvinyl alcohol (PVA) polymer and nitro blue tetrazolium (NBT) dye to measure low radiation doses effectively.
Methods: Various concentrations of NBT dye (ranging from 0.
The relationships of plasma profenofos and ethanol concentrations to clinical outcome in acute profenofos self-poisoning.
Clin Toxicol (Phila)
January 2025
Faculty of Medicine, South Asian Clinical Toxicology Research Collaboration, University of Peradeniya, Peradeniya, Sri Lanka.
Introduction: Many patients acutely self-poisoned with organophosphorus insecticides have co-ingested ethanol. Currently, profenofos 50% emulsifiable concentrate (EC50) is commonly ingested for self-harm in Sri Lanka. Clinical experience suggests that ethanol co-ingestion makes management more difficult.
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