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Calcium Chaos in Sarcoidosis: A Tale of Severe Hypercalcemia's Diagnostic Challenge.
Cureus
March 2024
Pulmonary and Critical Care Medicine, Saint Peter's University Hospital/Rutgers Robert Wood Johnson Medical School, New Brunswick, USA.
Sarcoidosis is a systemic inflammatory condition characterized by noncaseating granulomas. Lung involvement is typical, while extrapulmonary manifestations, notably lymphadenopathy, are observed in a significant proportion of cases. The etiology involves complex interactions among immune cells and mediators, resulting in granuloma formation capable of independently producing 1,25-dihydroxyvitamin D, leading to unregulated hypercalcemia and hypercalciuria.
View Article and Find Full Text PDFSpontaneous cervical hematoma caused by giant parathyroid adenoma in an elderly patient: A case report.
Med Int (Lond)
November 2023
Department of General and Digestive Surgery, Príncipe de Asturias Teaching Hospital, 28805 Madrid, Spain.
Article Synopsis
- Spontaneous cervical hematoma often arises from bleeding in or around the parathyroid gland, typically linked to conditions like giant adenomas or hyperplasia, and can lead to severe complications if it compresses the airway.
- For stable patients, treatment generally includes monitoring and possible delayed surgery, while those with airway issues require urgent surgical intervention.
- The case study discusses a 78-year-old patient with multiple health issues who experienced neck pain and respiratory problems due to a spontaneous cervical hematoma from a giant parathyroid adenoma, resulting in complicated post-operative recovery.
Nephrocalcinosis in a Transplanted Kidney: A New Sign of Chronic Tacrolimus Nephrotoxicity.
Saudi J Kidney Dis Transpl
November 2022
Department of Radiology, Qutaina Medical Center, Kuwait City, Kuwait.
Calcineurin inhibitors are potent immunosuppressive drugs in solid-organ transplantation and multiple autoimmune diseases. Their use is associated with the acute impairment of glomerular filtration and chronic interstitial fibrosis. The latter is mediated by the accumulation of matrix proteins.
View Article and Find Full Text PDFConcurrent Primary Hyperparathyroidism and Sarcoidosis in a Patient With Severe Hypercalcemia.
Cureus
September 2023
Internal Medicine, Saif Medical Center, Tulkarm, PSE.
Hypercalcemia is a common biochemical abnormality caused by various etiologies, with primary hyperparathyroidism (PHPT) and malignancies being the most common culprits. Differentiating between PTH-dependent and PTH-independent hypercalcemia is crucial in clinical practice. However, in certain clinical contexts, it is important to consider the rare occurrence of two separate conditions causing hypercalcemia simultaneously.
View Article and Find Full Text PDFAcute Inflammatory Arthropathy and Hypercalcemia Leading to a Diagnosis of Primary Hyperparathyroidism in a Patient With Known Sarcoidosis.
Cureus
June 2023
Internal Medicine/Rheumatology, New York Medical College at Saint Michael's Medical Center, Newark, USA.
Article Synopsis
- - Calcium pyrophosphate deposition disease (CPPD) is a type of arthritis caused by the buildup of calcium pyrophosphate crystals in joints, commonly diagnosed through x-rays or analyzing joint fluid.
- - An 87-year-old woman with sarcoidosis experienced acute joint pain and high calcium levels (hypercalcemia), initially thought to be due to her existing condition.
- - Further investigation into her hypercalcemia in light of her CPPD led to the discovery of primary hyperparathyroidism, demonstrating the need for thorough evaluations in similar cases.
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