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Xenobiotics Triggering Acute Intermittent Porphyria and Their Effect on Mouse Brain Respiratory Complexes.
J Xenobiot
February 2024
Research Center on Porphyrins and Porphyrias (CIPYP)-UBA-CONICET, Hospital of Clinics José de San Martín, Buenos Aires 1120, Argentina.
Heme enzyme dysfunction causes a group of diseases called porphyrias. Particularly, a decrease in porphobilinogen deaminase, involved in the third step of heme biosynthesis, leads to acute intermittent porphyria (AIP). Considering our previous works demonstrating the multiplicity of brain metabolisms affected by porphyrinogenic agents, this study aimed to elucidate whether they cause any alteration on the mitochondrial respiratory chain.
View Article and Find Full Text PDFIntegrating animal experiments, mass spectrometry and network-based approach to reveal the sleep-improving effects of Ziziphi Spinosae Semen and γ-aminobutyric acid mixture.
Chin Med
August 2023
Department of Bioengineering, Zhuhai Campus of Zunyi Medical University, Zhuhai, 519000, Guangdong, China.
Background: Ziziphi Spinosae Semen (ZSS) is a plant widely used as medicine and food in Asian countries due to its numerous health benefits. γ-aminobutyric acid (GABA), a non-proteinaceous amino acid, is one of the major inhibitory neurotransmitters with a relaxant function. In this study, a system pharmacology approach was employed to assess the effects of a mixture composed of ZSS and GABA (ZSSG) on sleep improvement.
View Article and Find Full Text PDFDonor-Acceptor Stenhouse Adduct Displaying Reversible Photoswitching in Water and Neuronal Activity.
J Am Chem Soc
August 2022
Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute for Science and Technology, Baldiri Reixac 10-12, Barcelona 08028, Spain.
The interest in the photochromism and functional applications of donor-acceptor Stenhouse adducts (DASAs) soared in recent years owing to their outstanding advantages and flexible design. However, their low solubility and irreversible conversion in aqueous solutions hampered exploring DASAs for biology and medicine. It is notably unknown whether the barbiturate electron acceptor group retains the pharmacological activity of drugs such as phenobarbital, which targets γ-aminobutyric acid (GABA)-type A receptors (GABARs) in the brain.
View Article and Find Full Text PDFThe combined use of gamma-aminobutyric acid and walnut peptide enhances sleep in mice.
Ann Palliat Med
October 2021
Department of Food Nutrition & Function Assessment Center, Beijing Institute of Nutritional Resources, Beijing, China.
Background: γ-aminobutyric acid (GABA) is a naturally occurring non-protein amino acid in the nervous system and has a wide range of physiological functions in the body. Walnut peptide (WP) contains high levels of arginine, aspartic acid, and glutamate, and has been shown to improve cognitive deficits and memory impairment in mice, while restoring antioxidant enzyme levels and reducing brain inflammatory mediators.
Methods: This study investigated the effects of GABA and WP, either alone or in combination, on sleep disturbances in mice.
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