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Deep learning-based anomaly detection using one-dimensional convolutional neural networks (1D CNN) in machine centers (MCT) and computer numerical control (CNC) machines.
PeerJ Comput Sci
October 2024
Digital Anti-aging Healthcare, Inje University, GIMHAE, Gyeongsangnam-do, Republic of South Korea.
Computer numerical control (CNC) and machine center (MCT) machines are mechanical devices that manipulate different tools using computer programming as inputs. Predicting failures in CNC and MCT machines before their actual failure time is crucial to reduce maintenance costs and increase productivity. This study is centered around a novel deep learning-based model using a 1D convolutional neural network (CNN) for early fault detection in MCT machines.
View Article and Find Full Text PDFA novel designed anti-PD-L1/OX40 bispecific antibody augments both peripheral and tumor-associated immune responses for boosting anti-tumor immunity.
Mol Cancer Ther
November 2024
Epimab Biotherapeutics, Shanghai, China.
Bispecific antibodies (BsAbs) combining simultaneous PD-L1 blockade and conditional co-stimulatory receptor activation have been developed to improve immune checkpoint therapy response. However, several PD-L1-based BsAbs have encountered clinical challenges, including insufficient activity or unexpected toxicity. In this study, we propose OX40 as a more suitable target partner for PD-L1-based BsAb design compared to ongoing clinical partners (CD27 and 4-1BB).
View Article and Find Full Text PDFAssessment of surface and groundwater quality in the Ctalamochita River basin, Argentina: hydrogeochemical characteristics and exploratory data analysis.
Environ Geochem Health
November 2024
Instituto Multidisciplinario de Investigación y Transferencia Agroalimentaria y Biotecnológica (IMITAB-CONICET), Instituto Académico Pedagógico de Ciencias Básicas y Aplicadas (IAPCByA), Universidad Nacional de Villa María (UNVM), Av. Arturo Jauretche 1555, CP 5900, Villa María, Córdoba, Argentina.
Freshwater and groundwater are important resources for the drinking water supporting agricultural and livestock activities in the Córdoba province, Argentina. The aim of this study was to assess the physicochemical and microbiological quality of surface water (n = 14) and groundwater (n = 17) sites in the middle-lower basin of the Ctalamochita River (Córdoba, Argentina) for human and animal consumption. A total of 18 physicochemical and five microbiological parameters were evaluated to determine the hydrogeological characteristics of both water resources and their suitability for human and animal consumption using the Water Quality Index (WQI).
View Article and Find Full Text PDFAdvantages and drawbacks of different methods to measure marginal gaps in fixed dental prostheses: A scoping review.
J Dent
December 2024
Department of Dental Surgery, Faculty of Dental Surgery, University of Malta, Msida, Malta.
Article Synopsis
- This review compares traditional and digital methods for assessing marginal gaps in fixed dental prostheses, highlighting the advantages and limitations of each technique.
- Traditional methods like Cross-Sectional Method (CSM) and Silicone Replica Technique (SRT) are established but have drawbacks, while newer digital techniques like Triple-Scan Method (TSM) and Optical Coherence Tomography (OCT) provide more detailed evaluations.
- The study indicates a knowledge gap in the literature, emphasizing the need for further exploration of digital methods for clinical applications in dental assessments.*
Isolation of Functional Human MCT Transporters in .
Cells
September 2024
Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Maersk Tower 7-9, DK-2200 Copenhagen N, Denmark.
Human monocarboxylate transporters (hMCTs) belong to the solute carrier 16 (SLC16) family of proteins and are responsible for the bi-directional transport of various metabolites, including monocarboxylates, hormones, and aromatic amino acids. Hence, the metabolic role of hMCTs is undisputable, as they are directly involved in providing nutrients for oxidation and gluconeogenesis as well as participate in circulation of iodothyronines. However, due to the difficulty in obtaining suitable amounts of stable hMCT samples, the structural information available for these transporters is limited, hindering the development of effective therapeutics.
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