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Epidemiological and Clinical Characteristics of Pediatric Acute Drug Intoxications: A Retrospective Analysis.
Children (Basel)
December 2024
County Hospital Craiova, Department of Anatomy, University of Medicine and Pharmacy, Discipline of Anatomy, 200349 Craiova, Romania.
Background/objectives: Acute drug intoxications (ADIs) are a significant concern in pediatric healthcare, contributing to both accidental and intentional morbidity. This study aimed to analyze the demographic, clinical, and therapeutic characteristics of pediatric ADI cases to identify trends and inform preventive strategies.
Methods: This retrospective study included 120 cases of pediatric ADI admitted to the Second Pediatric Clinic of Craiova County Emergency Clinical Hospital in 2022 and 2023.
Case report: Accidental aconitine poisoning caused by the inappropriate use of a type of Chinese patent medicine.
Front Pharmacol
January 2025
Department of Pharmacy, Cheeloo College of Medicine, The Hospital of Shandong University, Shandong University, Jinan, Shandong, China.
Background: Compound schizonepeta fumigation lotion is a type of Chinese patent medicine for external use. It has the effect of dispelling wind, eliminating dampness, reducing swelling, and relieving pain. Clinically, it is used for anal fumigation and treatment of external hemorrhoids, anal fissures, and other diseases.
View Article and Find Full Text PDFMace Poisoning: Accidental Toxic Ingestion in a Child Leading to a Reversible Coma.
Cureus
December 2024
Psychology Department, Ministry of Defence, Riyadh, SAU.
Nutmeg and mace are commonly known for their medicinal and culinary properties. The chemical compounds found in nutmeg and mace, notably myristicin, elemicin, and safrole, have been implicated in the psychoactive and anticholinergic effects that are the result of acute toxicity. Cases of mace toxicity are not as commonly reported as nutmeg toxicity.
View Article and Find Full Text PDFToluene Toxicity in the Brain: From Cellular Targets to Molecular Mechanisms.
Annu Rev Pharmacol Toxicol
January 2025
Department of Pharmacology, Addiction Science, and Toxicology, College of Medicine, The University of Tennessee Health Science Center, Memphis, Tennessee, USA; email:
Toluene intoxication constitutes a persistent public health problem worldwide. While most organs can be damaged, the brain is a primary target whether exposure is accidental, occupational, or recreational. Interventions to prevent/revert brain damage by toluene are curtailed by the scarce information on the molecular targets and mechanisms mediating toluene's brain toxicity and the common exposure to other neurotoxins and/or coexistence of neurological/psychiatric disorders.
View Article and Find Full Text PDFIdentification of distinct pesticide poisoning patterns in Brazil: a cross-sectional cluster analysis of epidemiological data.
Int Arch Occup Environ Health
January 2025
Department of Quantitative Methods, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.
Purpose: This study aimed to identify distinct patterns of pesticide poisoning in Brazil through the cluster analysis of epidemiological data from 2011 to 2019.
Methods: A cross-sectional analysis of 49,233 confirmed pesticide poisoning cases was conducted using multiple correspondence analysis and hierarchical clustering. Data from the Brazilian Notifiable Diseases Information System were analyzed by region, demographics, and exposure types.
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