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Paracetamol, its metabolites, and their transfer between maternal circulation and fetal brain in mono- and combination therapies.
Pharmacol Rep
January 2025
Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, VIC, 3004, Australia.
Background: Due to its availability and perceived safety, paracetamol is recommended even during pregnancy and for neonates. It is used frequently alone or in combination with other drugs required for the treatment of various chronic conditions. The aim of this study was to investigate potential effects of drug interactions on paracetamol metabolism and its placental transfer and entry into the developing brain.
View Article and Find Full Text PDFRadioprotective Effects of Vitamin C, Cimetidine, and Famotidine on Lipid Peroxidase and Hepatic Glutathione Levels in Mouse Liver.
Int J Cell Biol
January 2025
Department of Biotechnology and Plant Breeding, Sari Agricultural Sciences and Natural Resources University (SANRU), Sari, Iran.
Radiation therapy is one of the most effective treatments for approximately 60% of patients with cancer. During radiation exposure, the overproduction of reactive oxygen species (ROS) disrupts the lipid layer of the membrane, leading to subsequent peroxide radical formation. Cimetidine (Cim) and famotidine (Fam) are histamine H2 receptor antagonists (H2 blocker), also known as peptic ulcer drugs, that exert radioprotective effects.
View Article and Find Full Text PDFExploring Cimetidine as a Potential Therapeutic Attenuator against Amyloid Formation in Parkinson's Disease: Spectroscopic and Microscopic Insights into Alpha-Synuclein and Human Insulin.
ACS Chem Neurosci
December 2024
Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, Uttar Pradesh 202001, India.
Neurodegenerative diseases, notably Alzheimer's and Parkinson's, hallmark their progression through the formation of amyloid aggregates resulting from misfolding. While current therapeutics alleviate symptoms, they do not impede disease onset. In this context, repurposing existing drugs stands as a viable therapeutic strategy.
View Article and Find Full Text PDFIdentification of biological significance of different stages of varicose vein development based on mRNA sequencing.
Sci Rep
September 2024
Department of Vascular Surgery, Shaanxi Provincial People's Hospital, No.256 Youyi west Road, Xi'an, 710068, Shaanxi, China.
Article Synopsis
- A study looked at how normal veins can become varicose (VV) and possibly lead to blood clots (SVT) by using samples and special tests to find important genes involved in these changes.
- They found six key genes that might help explain how VV progresses or gets better, especially focusing on a gene called DACT3, which seems to stop VV from getting worse.
- The research suggests a drug called Cimetidine could help treat VV and SVT, and the findings can help understand how the immune system is involved in these vein problems.
Renal Functional Reserve in Naïve HIV Patients.
G Ital Nefrol
August 2024
Nephrology Division. Clínica de la Costa. Barranquilla, Colombia.
Renal functional reserve (RFR) is the kidney capability of increasing its basal glomerular filtration rate (GFR) at least 20% after an adequate stimulus. Renal disorders have been reported in seropositive HIV patients, particularly the decrease in glomerular filtration rate (eGFR), nephrotic syndrome, and proximal tubular deficiency associated with the disease itself or the use of some anti-retroviral treatments. Thus, it was decided to carry out a prospective study in order to evaluate if RFR test was preserved in naive HIV patients.
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