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Chemical leukoderma: An insight of pathophysiology and contributing factors.
Toxicol Ind Health
August 2024
Centre for Medical Biotechnology, Maharshi Dayanand University, Rohtak, India.
Article Synopsis
- - Chemical leukoderma is a skin condition caused by chemical exposure, leading to loss of skin pigment due to the death of melanocytes, the cells responsible for pigmentation.
- - This condition is particularly concerning in developing countries like India, with links identified between household chemicals derived from phenols and catechol and its onset.
- - Its development is influenced by a combination of genetic predisposition and environmental factors, with recent studies highlighting the significant role of chemical exposure in its initiation and progression.
An Excimer Laser-Induced Eruptive Sebaceous Hyperplasia.
Ann Dermatol
November 2023
Department of Dermatology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
Article Synopsis
- * A 59-year-old woman developed noticeable raised skin bumps on her face after undergoing 16 sessions of 308-nm excimer laser treatment for vitiligo, with the lesions appearing in the areas that had been treated.
- * The patient's skin samples showed enlarged sebaceous glands, supporting existing research that chronic sun exposure can lead to SH, highlighting a potential side effect of excimer laser therapy in vulnerable individuals.
Vitiligo and the Role of Newer Therapeutic Modalities.
Cureus
November 2022
Department of Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Science (Deemed to be University), Wardha, IND.
Our understanding of the etiology of vitiligo, which is now categorically recognized as an autoimmune illness characterized by the occurrence of chalky-white patches over the skin as a consequence of focal melanocyte loss, has made significant strides in recent years. The notion that vitiligo results from a mix of etiologic factors that affect melanocyte functionality rather than solely due to underlying mutations, melanocytes reacting to chemical or radiation exposure, or hyperreactive T cells, has undoubtedly remained consistent. Since then, new research has contributed to our understanding of gradual depigmentation.
View Article and Find Full Text PDFRole of chemical exposure in the incidence of vitiligo: a case-control study in Tunisia.
Libyan J Med
December 2023
Occupational Department and Health Disease Hedi Chaker University Hospital, University of Sfax, Sfax, Tunisia.
Vitiligo is a multifactorial dermatosis with many etiological hypotheses that have been suggested for its occurrence. To our knowledge, few epidemiological studies are available on vitiligo induction factors and particularly on the role of exposure to chemicals in the onset of the disease has been found. Therefore, there is need to investigate the relationship between vitiligo and chemical exposures in order to understand this mysterious disease.
View Article and Find Full Text PDFCurrent Concepts of Vitiligo Immunopathogenesis.
Biomedicines
July 2022
Department of Dermatovenerology, Medical Faculty, University of Rijeka, Clinical Hospital Center Rijeka, Krešimirova 42, 51000 Rijeka, Croatia.
Vitiligo is an acquired immune-mediated disorder of pigmentation clinically characterized by well-defined depigmented or chalk-white macules and patches on the skin. The prevalence of vitiligo varies by geographical area, affecting 0.5% to 2% of the population.
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