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Pallidal Spike-Train Variability and Randomness Are the Most Important Signatures to Classify Parkinson's Disease and Cervical Dystonia.
Eur J Neurosci
January 2025
Case Western Reserve University, Cleveland, Ohio, USA.
Movement disorders such as Parkinson's disease (PD) and cervical dystonia (CD) are associated with abnormal neuronal activity in the globus pallidus internus (GPi). Reduced firing rate and presence of spiking bursts are typical for CD, whereas PD is characterized by high frequency tonic activity. This research aims to identify the most important pallidal spiking parameters to classify these conditions.
View Article and Find Full Text PDFMolecular Understanding of CO Absorption by Choline Chloride/Urea Confined within Nanoslits.
Langmuir
January 2025
College of Chemical Engineering, State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing 211816, PR China.
Clarifying the potential relationship between the microstructure of nanoconfined choline chloride/urea (ChClU) and CO absorption performance is key to understanding the abnormal increase in CO under nanoconfinement. In this study, we used molecular dynamics simulations and grand canonical Monte Carlo (GCMC) to systematically study the mechanism underlying the absorption of CO by ChClU within nanoslits. According to the spatial distribution, ChClU can form two different laminar regions within nanoslits, namely, the interfacial region (region I) and beyond region I (region II).
View Article and Find Full Text PDFComparison of Fertilization Outcomes between Normal and T-Shaped Uteri, Diagnosed by Hysterosalpingography in Women with infertility: A Retrospective Cohort Study.
Int J Fertil Steril
January 2025
Department of Basic and Population Based Studies in NCD, Reproductive Epidemiology Research Center, Royan Institute, ACECR, Tehran, Iran.
Background: T-shaped uterus is a subclass of dysmorphic uteri according to the European Society of Human Reproduction and Embryology (ESHRE) classification. A T-shaped uterus might be related to poor reproductive outcomes or pregnancy complications. We aim to compare the success rates of fertilization (IVF) between individuals with a normal uterus and those with a T-shaped uterus identified through Hysterosalpingography.
View Article and Find Full Text PDFComprehensive multi-omics analysis reveals the mechanism of hepatotoxicity induced by Emilia sonchifolia (L.) DC.
J Ethnopharmacol
January 2025
Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China. Electronic address:
Ethnopharmacological Relevance: Emilia sonchifolia is a very widely used traditional Chinese medicine, with the efficacy of heat-clearing, detoxicating, dissipating blood stasis, reducing swelling and relieving pain. As a widely used traditional miao herb, Emilia sonchifolia is often used to treat upper respiratory tract infections, oral ulcer, pneumonia, mastitis, enteritis, bacillum, urinary tract infection, sores, eczema, falls and injuries, etc. In fact, many cases of liver injury caused by Emilia sonchifolia have been reported clinically.
View Article and Find Full Text PDFApplication of a near-infrared viscosity-responsive fluorescent probe for lysosomal targeting in fatty liver mice.
Bioorg Chem
January 2025
Key Laboratory for Tibet Plateau Phytochemistry of Qinghai Province, College of Pharmacy, Qinghai Minzu University, Xining 810007 Qinghai, China; State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China. Electronic address:
Viscosity is a fundamental property in biological systems, influencing organelle function and molecular diffusion. Abnormal viscosity is associated with diseases such as metabolic disorders, neurodegeneration, and cancer. Lysosomes, central to cellular degradation and recycling, are sensitive to viscosity changes, which can disrupt enzymatic activity and cellular homeostasis.
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