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Effect of motor process-related priming via repeated transcranial magnetic stimulation on embodiment perception during mirror visual feedback: a pilot study.
Front Neurosci
November 2024
Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Article Synopsis
- Non-invasive brain stimulation techniques, like transcranial magnetic stimulation (TMS), were combined with mirror visual feedback (MVF) to improve therapeutic effectiveness, though previous methods didn't fully leverage the embodiment perception related to MVF.
- The study aimed to evaluate how repeated TMS over specific brain areas (the primary motor cortex and dorsolateral prefrontal cortex) influenced participants' embodiment perception while using MVF during motor tasks.
- Results indicated that TMS, particularly over the dorsolateral prefrontal cortex, reduced task completion latency and increased the perception of embodiment during MVF, suggesting that TMS can enhance rehabilitation strategies by improving the embodiment experience.
Spinal Muscular Atrophy Update in Best Practices: Recommendations for Treatment Considerations.
Neurol Clin Pract
February 2025
Cure SMA (MKS); Clinical Care Education (JD), Cure SMA; Neurology and Pediatrics (DBG), Children's National, and National Institute of Neurological Diseases and Stroke, National Institutes of Health; Division of Neurology (WBB), Department of Pediatrics, Vanderbilt University; Department of Neurology (BTD), Boston Children's Hospital, Harvard Medical School; Department of Neurology (BHE), The Ohio State University Wexner Medical Center; Child Neurology (MVF), Indiana University; Division of Neuropediatrics (AK), Development and Rehabilitation, Department of Pediatrics, Inselspital, Bern University Hospital; Pediatric Neuromuscular (JK), Helen DeVos Children's Hospital; Neurology (CMP), Children's Hospital of the King's Daughters; Department of Pediatrics (AV), Division of Neurology, University of Arkansas for Medical Sciences, Arkansas Children's Hospital; and Department of Anesthesiology (RJG), Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School.
Article Synopsis
- * A systematic literature review and feedback from specialized health care providers and SMA community members helped identify important factors that influence decisions regarding treatment initiation, changes, or discontinuation.
- * Key considerations in treatment decisions include patient age, genetic factors, treatment safety, and quality of life, with an emphasis on monitoring outcomes over a period of 6-12 months before making significant treatment changes.
Generation of Connective Tissue-Free Microvascular Fragment Isolates from Subcutaneous Fat Tissue of Obese Mice.
Tissue Eng Regen Med
December 2023
Institute for Clinical and Experimental Surgery, Saarland University, 66421, Homburg, Germany.
Background: Microvascular fragment (MVF) isolates are generated by short-term enzymatic digestion of adipose tissue and contain numerous vessel segments for the vascularization of tissue defects. Recent findings indicate that the functionality of these isolates is determined by the quality of the fat source. Therefore, we compared MVF isolates from subcutaneous adipose tissue of obese and lean mice.
View Article and Find Full Text PDFMagnetic Fluorescent Bead-Based Dual-Reporter Flow Analysis of PDL1-Vaxx Peptide Vaccine-Induced Antibody Blockade of the PD-1/PD-L1 Interaction.
J Vis Exp
July 2023
Department of Obstetrics & Gynecology, The Ohio State University Wexner Medical Center; The James Comprehensive Cancer Center;
The inhibition of checkpoint receptors (PD-1, PD-L1, and CTLA-4) with monoclonal antibodies has shown great benefit in clinical trials for treating cancer patients and has become a mainstay approach in modern cancer immunotherapy. However, only a subset of patients respond to checkpoint monoclonal antibody immunotherapy. Therefore, it is urgent to develop new therapeutic strategies against cancer.
View Article and Find Full Text PDFPreclinical Studies of a Novel Human PD-1 B-Cell Peptide Cancer Vaccine PD1-Vaxx From BALB/c Mice to Beagle Dogs and to Non-Human Primates (Cynomolgus Monkeys).
Front Oncol
May 2022
Department of Obstetrics & Gynecology, The Ohio State University Wexner Medical Center, Columbus, OH, United States.
Immunotherapy with monoclonal antibodies to checkpoint inhibitors against the PD-1/PD-L1 signaling pathway is a landmark achievement in cancer therapy. Some anti-PD-1 inhibitors such as nivolumab and pembrolizumab have shown clinical success, in a percentage of patients with prolonged survival rates. However, adverse effects accompany these benefits.
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