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A comparison between IEEC, a new biodegradable particulate contrast medium, and iohexol in a tumor model of computed tomography imaging of the liver.
Invest Radiol
June 1993
Department of Experimental Research, University of Lund, Malmö General Hospital, Sweden.
Rationale And Objectives: Higher contrast between normal and pathologic tissues in the liver may enable detection of smaller lesions in computed tomography (CT). This can be obtained using a liver-specific contrast medium. The authors evaluate a new agent, IEEC (1'-Ethyloxycarbonyloxy)-ethyl-5-acetylamino-3-(N-methyl-acetylami no)-2,4,6- triiodo-benzenecarboxylate), in an animal model, as a potential contrast agent for CT scanning of the liver.
View Article and Find Full Text PDFEarly effect of gadopentetate and iodinated contrast media on rabbit kidneys.
Invest Radiol
November 1992
Department of Experimental Research, University of Lund, Sweden.
Rationale And Objectives: The authors compared the physiologic and nephrotoxic effects of the magnetic resonance imaging contrast medium gadopentetate with two conventional radiographic contrast media.
Methods: Rabbits were injected intravenously with one of the following solutions: 1) gadopentetate (0.1 M); 2) iohexol (300 mg I/mL); 3) metrizoate (300 mg I/mL); and 4) NaCl (0.
Contrast media and pain in patients with acute ureteral stone obstruction. A comparative study with iohexol and metrizoate.
Acta Radiol
September 1990
Department of Radiology, University of Umeå, Sweden.
A randomized study was conducted in 43 patients who were in pain due to acute ureteral obstruction. Emergency urography was performed in all patients, using either a low osmolar non-ionic (iohexol) or a high osmolar ionic (metrizoate) contrast medium. Increase of pain following injection of contrast media was found in 56 percent of all patients.
View Article and Find Full Text PDFInfluence of urography on renal function in children. A double blind study with metrizoate and iohexol.
Acta Radiol
May 1990
Department of Pediatric Radiology, University Hospital, Oslo, Norway.
Thirty-two children were given either metrizoate or iohexol for urography in a double blind study. Mild to moderate adverse reactions were observed in all patients receiving metrizoate (15/15) and in 4 receiving iohexol (4/17). Alkaline phosphatase in urine was significantly increased 4 hours after the injection of both media, but had returned to pre-injection levels 16 hours later.
View Article and Find Full Text PDFA micropuncture assessment of the effects of contrast media of different osmolality.
Invest Radiol
October 1988
Department of Physiology and Medical Biophysics, University of Lund, Sweden.
The pathophysiology of radiographic contrast media-induced acute renal failure is unclear. Different causes are suggested, including hypertonicity, charged molecules, and toxicity of the media. This study deals with hemodynamic changes after injection of contrast media of high osmolarity iohexol, and metrizoate.
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