The Authors have studied the ultrastructure of human skin in a particular anomalous form of post-mortal transformation: the so called corification. Some structures (cell membranes, desmosomes, mitochondria, nuclear envelopes) are well preserved, while other structures (such as endoplasmic reticulum) are upset. These observations suggested that in the corification endogenous and exogenous enzymatic actions are extremely inhibited.
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Open Heart
January 2025
Center for Congenital Heart Disease Amsterdam Leiden (CAHAL), Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands
Background: Short-term improvements in quality of life (QOL) have been reported in adult congenital heart disease patients with systemic right ventricle (sRV) failure after treatment with sacubitril/valsartan. This study aimed to evaluate the medium-term QOL changes in sRV failure patients treated with sacubitril/valsartan.
Methods: In this single-centre, prospective cohort study, patients with symptomatic sRV failure completed the Netherlands Organisation for Applied Scientific Research/Academic Hospital Leiden Questionnaire for Adult's Health-Related Quality of Life (TAAQOL) at baseline and after starting treatment with sacubitril/valsartan.
Int J Biol Macromol
January 2025
Key Laboratory of Bionic Engineering (Ministry of Education), College of Biological and Agricultural Engineering, Jilin University, Changchun 130022, China. Electronic address:
Inspired by the superhydrophobic characteristics of duck feathers this research introduced an intelligent, responsive, and eco-friendly food packaging film constructed from carboxymethyl cellulose (CMC) and gelatin (Gel). The film successfully mimics the asymmetric, bionic, barbed structure of a duck feather, offering outstanding hydrophobicity and moisture vapor resistance characteristics. Moreover, the bionic film demonstrated good mechanical strength, film-forming ability and biodegradability.
View Article and Find Full Text PDFEnviron Res
January 2025
Energy Convergence Research Center, Seoul National University of Science and Technology, 232 Gongneung-ro, Nowon-gu, Seoul, 01811, Republic of Korea; Department of Fine Chemistry, Seoul National University of Science and Technology, 232, Gongneung-ro, Nowon-gu, Seoul 01811, Republic of Korea; Institute for Applied Chemistry, Seoul National University of Science and Technology, 232 Gongneung-ro, Nowon-gu, Seoul 01811, Republic of Korea. Electronic address:
Unregulated discharge of antibiotics in waterbodies has posed significant threat to the aquatic flora and fauna in post-pandemic times. This alarming situation has ascertained the need for suitable sensors to detect persistent antibiotic residues. In this context, functional hybrid materials centralized on reticular metal-organic frameworks (MOFs)/composites have been a research hot spot for photoelectrochemical host-guest recognition events over the past two decades.
View Article and Find Full Text PDFStructure
January 2025
Key Laboratory of Pathogen Infection Prevention and Control (Ministry of Education), National Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China; NHC Key Laboratory of Systems Biology of Pathogens, National Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China; State Key Laboratory of Respiratory Health and Multimorbidity, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. Electronic address:
Broadly neutralizing antibodies (nAbs) are vital therapeutic tools to counteract both pandemic and seasonal influenza threats. Traditional strategies for optimizing nAbs generally rely on labor-intensive, high-throughput mutagenesis screens. Here, we present an innovative structure-based design framework for the optimization of nAbs, which integrates epitope-paratope analysis, computational modeling, and rational design approaches, complemented by comprehensive experimental assessment.
View Article and Find Full Text PDFAcc Mater Res
January 2025
School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30322, United States.
Increasing demand for high-purity fine chemicals and a drive for process intensification of large-scale separations have driven significant work on the development of highly engineered porous materials with promise for sorption-based separations. While sorptive separations in porous materials offer energy-efficient alternatives to longstanding thermal-based methods, the particulate nature of many of these sorbents has sometimes limited their large-scale deployment in high-throughput applications such as gas separations, for which the necessary high feed flow rates and gas velocities accrue prohibitive operational costs. These processability limitations have been historically addressed through powder shaping methods aimed at the fabrication of structured sorbent contactors based on pellets, beads or monoliths, commonly obtained as extrudates.
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