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An integrative review on the risk factors, prevention, and control strategies for carbapenem-resistant colonization in critically ill patients.
Front Microbiol
January 2025
Department of Critical Care Medicine, Qilu Hospital, Shandong University, Jinan, China.
The presence of carbapenem-resistant (CR) has become one of the leading causes of life-threatening, hospital-acquired infections globally, especially with a notable prevalence in intensive care units (ICUs). The cross-transmission of microorganisms between patients and the hospital setting is crucial in the development of CR colonization and subsequent infections. Recent studies indicate that colonization typically precedes infection, suggesting the effectiveness and necessity of preventing CR colonization as a primary method to lower infection risks.
View Article and Find Full Text PDFValidation of SCAI Shock Staging in Critically Ill Medical Intensive Care Unit Patients With Sepsis and Septic Shock.
J Community Hosp Intern Med Perspect
January 2025
Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.
Purpose: This study evaluated the predictive value of SCAI shock staging for mortality in patients with sepsis and septic shock admitted to the medical ICU.
Materials And Methods: This is a single-center historical cohort study. We analyzed data for adults (≥18-year-old) admitted to the medical ICU at Mayo Clinic St.
Bladder Injury and Urinary Tract Infection Following Low-Energy Pelvic Fracture in an Elderly Patient.
Cureus
December 2024
Department of Internal Medicine, Kyoto Min-iren Asukai Hospital, Kyoto, JPN.
This case report presents an 86-year-old female patient who developed a urinary tract injury and infection following a pelvic fracture caused by a bedside fall during hospitalization for pneumonia. The patient experienced fever with chills and rigors, prompting antibiotic treatment. Imaging revealed an ischial tuberosity fracture with potential bone fragment retention in the bladder wall.
View Article and Find Full Text PDFAcute respiratory distress syndrome (ARDS): from mechanistic insights to therapeutic strategies.
MedComm (2020)
February 2025
Department of Emergency Ruijin Hospital, Shanghai Jiaotong University School of Medicine Shanghai China.
Acute respiratory distress syndrome (ARDS) is a clinical syndrome of acute hypoxic respiratory failure caused by diffuse lung inflammation and edema. ARDS can be precipitated by intrapulmonary factors or extrapulmonary factors, which can lead to severe hypoxemia. Patients suffering from ARDS have high mortality rates, including a 28-day mortality rate of 34.
View Article and Find Full Text PDFProbiotic biofilm modified scaffolds for facilitating osteomyelitis treatment through sustained release of bacteriophage and regulated macrophage polarization.
Mater Today Bio
February 2025
Department of Orthopedic Trauma and Microsurgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, Hubei, China.
Osteomyelitis has gradually become a catastrophic complication in orthopedic surgery due to the formation of bacterial biofilms on the implant surface and surrounding tissue. The therapeutic challenges of antibiotic resistance and poor postoperative osseointegration provide inspiration for the development of bioactive implants. We have strategically designed bioceramic scaffolds modified with (LR) and bacteriophages (phages) to achieve both antibacterial and osteogenic effects.
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