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Ten-year report on the first patient with HeartMate 3 left ventricular assist device.
J Heart Lung Transplant
December 2024
Department of Cardiac-, Thoracic-, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany. Electronic address:
Identification and validation of novel engineered AAV capsid variants targeting human glia.
Front Neurosci
August 2024
Molecular Neuromodulation, Department of Experimental Medical Science, Faculty of Medicine, Lund University, Lund, Sweden.
Direct neural conversion of endogenous non-neuronal cells, such as resident glia, into therapeutic neurons has emerged as a promising strategy for brain repair, aiming to restore lost or damaged neurons. Proof-of-concept has been obtained from animal studies, yet these models do not efficiently recapitulate the complexity of the human brain, and further refinement is necessary before clinical translation becomes viable. One important aspect is the need to achieve efficient and precise targeting of human glial cells using non-integrating viral vectors that exhibit a high degree of cell type specificity.
View Article and Find Full Text PDFBrave new world: expanding home care in stem cell transplantation and advanced therapies with new technologies.
Front Immunol
May 2024
Home Hospitalization Department, University Hospital "Marques de Valdecilla" - Instituto de Investigación Valdecilla (IDIVAL), Santander, Spain.
Hematopoietic stem cell transplantation and cell therapies like CAR-T are costly, complex therapeutic procedures. Outpatient models, including at-home transplantation, have been developed, resulting in similar survival results, reduced costs, and increased patient satisfaction. The complexity and safety of the process can be addressed with various emerging technologies (artificial intelligence, wearable sensors, point-of-care analytical devices, drones, virtual assistants) that allow continuous patient monitoring and improved decision-making processes.
View Article and Find Full Text PDFMyeloablative vs nonmyeloablative consolidation for primary central nervous system lymphoma: results of Alliance 51101.
Blood Adv
June 2024
UCSF Medical Center, Helen Diller Family Comprehensive Cancer Center, San Francisco, CA.
Although it is evident that standard-dose whole-brain radiotherapy as consolidation is associated with significant neurotoxicity, the optimal consolidative strategy for primary central nervous system lymphoma (PCNSL) is not defined. We performed a randomized phase 2 clinical trial via the US Alliance cancer cooperative group to compare myeloablative consolidation supported by autologous stem cell transplantation with nonmyeloablative consolidation after induction therapy for PCNSL. To our knowledge, this is the first randomized trial to be initiated that eliminates whole-brain radiotherapy as a consolidative approach in newly diagnosed PCNSL.
View Article and Find Full Text PDF[Strolling through the glorious years of Alveolar Surgery, bravely stepping onto the path of practice and innovation].
Zhonghua Kou Qiang Yi Xue Za Zhi
April 2024
Xi'an Medcial University, School of Stomatology, The Third Affiliated Hospital, Xi'an 710065, China.
This article summarizes and organizes relevant publications in journals, along with a review of medical history, systematically summarizing the development process of dental alveolar surgery in China. The initial establishment phase (1935-1952) marked the starting point of Chinese Alveolar Surgery. Despite the impact of wars, it laid the foundation for subsequent research and practice.
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