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The treatment journey of children with moderate to severe atopic dermatitis in Türkiye: unmet needs.
Turk J Pediatr
July 2024
Department of Pediatric Allergy, Hacettepe University School of Medicine, Ankara, Türkiye.
Background: Atopic dermatitis (AD) substantially burdens individuals, families, and healthcare systems. We aimed to document the treatment journey of pediatric patients with moderate-to-severe AD in a referral center based in our country.
Methods: This retrospective study reviewed patients aged 1-18 years diagnosed with AD, seeking systemic treatment recommendations from the "pediatric allergy and dermatology multidisciplinary team meeting".
Virilizing adrenocortical carcinoma in a female child of Li-Fraumeni syndrome.
Indian J Pathol Microbiol
July 2024
Department of Pathology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India.
Adrenocortical carcinoma is a rare malignancy and even rarer in infancy. Most of these tumors in the pediatric age group are hormonally active and predominantly present with virilization. We report a case of a 1-year-3-month-old female child presenting with virilization.
View Article and Find Full Text PDFUltra-low-dose continuous combined estradiol and dydrogesterone in postmenopausal women: A pooled safety and tolerability analysis.
Gynecol Endocrinol
December 2024
Division of Obstetrics and Gynecology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Article Synopsis
- The study evaluated the safety and tolerability of ultra-low dose estradiol and dydrogesterone among postmenopausal women using data from three clinical trials.
- A total of 1027 participants were analyzed, revealing that the rates of treatment-emergent adverse events (TEAEs) were comparable between the treatment (E0.5/D2.5 mg) and placebo groups.
- While the treatment group saw a higher incidence of breast pain and uterine hemorrhage, the overall conclusion was that the ultra-low dose combination was well tolerated without significant increases in adverse events compared to placebo.
A meta-analysis of bariatric surgery in patients with obesity and polycystic ovary syndrome.
Asian J Surg
December 2024
Department of Gynecology, The Affiliated Changzhou Second People's Hospital of Nanjing Medical University, 213000, Changzhou, Jiangsu, China. Electronic address:
Polycystic ovary syndrome (PCOS) is a multifactorial disease, which is closely related to obesity. This study evaluated the efficacy of bariatric surgery on obesity complicated with PCOS through meta-analysis. PubMed, Cochrane, EMbase, and WOS databases were searched from 2012 to November 2022.
View Article and Find Full Text PDFA Novel Mutation in the Gene Causes Severe Insulin Resistance and Rabson-Mendenhall Syndrome in a Paraguayan Patient.
Int J Mol Sci
March 2024
Department of Pediatrics, University Children's Hospital Bern, Inselspital, 3010 Bern, Switzerland.
Rabson-Mendenhall syndrome (RMS) is a rare autosomal recessive disorder characterized by severe insulin resistance, resulting in early-onset diabetes mellitus. We report the first case of RMS in a Paraguayan patient. The patient is a 6-year-old girl who presented with hypertrichosis, acanthosis nigricans, nephrocalcinosis, and elevated levels of glucose and insulin that served as diagnostic indicators for RMS.
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