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Multiple liquid crystalline geometries of highly compacted nucleic acid in a dsRNA virus.
Nature
June 2019
Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Characterizing the genome of mature virions is pivotal to understanding the highly dynamic processes of virus assembly and infection. Owing to the different cellular fates of DNA and RNA, the life cycles of double-stranded (ds)DNA and dsRNA viruses are dissimilar. In terms of nucleic acid packing, dsDNA viruses, which lack genome segmentation and intra-capsid transcriptional machinery, predominantly display single-spooled genome organizations.
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