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A Multiscale Mathematical Model for Fetal Gas Transport and Regulatory Systems During Second Half of Pregnancy.
Int J Numer Method Biomed Eng
January 2025
Cardiovascular Biomechanics, Biomedical Engineering, Eindhoven University of Technology, The Netherlands.
Fetal asphyxia, a condition resulting from the combined effects of hypoxia and hypercapnia, leads to approximately 900,000 annual deaths worldwide. One cause is umbilical cord compression during labor-induced uterine contractions, disrupting the transport of metabolites to and from the placenta, and resulting in asphyxia. Current fetal well-being assessment relies on monitoring fetal heart rate and uterine contractions as indicators of oxygen delivery to the brain.
View Article and Find Full Text PDFPost Mortem Molecular Biomarkers of Asphyxia: A Literature Review.
Int J Mol Sci
October 2024
Department of Medical and Surgical Sciences, Institute of Legal Medicine, "Magna Graecia" University, 88100 Catanzaro, Italy.
Asphyxia is a critical condition characterized by inadequate oxygen supply to the body. Post mortem diagnostics of asphyxia present significant challenges in forensic pathology, particularly when there are equivocal signs during autopsy or uncertain circumstantial data. The identification of biochemical biomarkers that indicate asphyxia has emerged as a promising area of research, as these markers can provide vital insights into the physiological changes occurring at the cellular level during asphyxiation.
View Article and Find Full Text PDFArticle Synopsis
- - The study examines how factors like gestational age, birth weight, delivery mode, and gender influence the measurement of blood pH and gas analytes (BPGA) in newborns, particularly healthy preterm and term infants.
- - Results indicate that preterm infants have significantly different BPGA levels compared to term infants, influenced by their delivery mode and gender, particularly in terms of carbon dioxide levels and hemoglobin types.
- - The findings suggest that BPGA measurements could be unreliable due to these perinatal characteristics, highlighting the need for further research to establish reliable reference values for different newborn populations.
Quantitative determination of nitrous oxide in human blood by HS-GC-MS: forensic application of two fatal poisoning cases.
Forensic Sci Int
July 2024
Department of Forensic Toxicology, Academy of Forensic Science, Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Science Platform, Key Laboratory of Forensic Sciences, Ministry of Justice, Shanghai 200063, PR China. Electronic address:
Nitrous oxide (NO), also known as laughing gas, has a euphoric effect and is becoming increasingly popular as a recreational inhalant drug. Deaths caused by recreational nitrous oxide abuse are rare, but may still occur. Although some methods for the quantification of NO by GC-MS have been reported, elimination of carbon dioxide interference and the choice of a suitable internal standard remain current limitations to accurate NO quantification.
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