150 cerebrospinal fluids from MS patients (85 cases) and patients with different neurological diseases (65 cases) were investigated for their glia-specific content. The demonstration was made quantitatively by means of modified passive hemagglutination tests. The brain-specific glycoprotein was examined for its possible endogenous antigen and/or antibody properties in the cerebrospinal fluid (csf). It could only be demonstrated in the CSF as antigen. CSF with a quantitatively detectable glia-specific protein content- recognizable by a significant increase in titer - were set in relation to other CSF parameters such as cell count, total protein and globulin ratio, and investigated for possible relationships to the clinical syndromes mentioned and their development. A firm correlation was found between the glia-specific protein content and the total protein content of the CSF with retained equivalence.
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