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Tracking acute flaccid paralysis in Niger: a half-decade epidemiological portrait (2016-2021).
BMC Infect Dis
January 2025
Bureau de L'Organisation Mondiale de La Santé (OMS), Niamey, Niger.
Background: Recently, a total of 74 circulating vaccine-derived poliovirus (cVDPV) outbreaks were detected in 39 countries, with 672 confirmed Acute Flaccid Paralysis (AFP) cases identified in 27 countries. Despite progress, Niger experienced cVDPV outbreaks in 2018, highlighting the importance of maintaining AFP surveillance as a tool for polio eradication. This analysis aims to comprehensively assess AFP surveillance trends, patterns, and challenges in Niger, offering insights for public health initiatives in conflict-affected contexts.
View Article and Find Full Text PDFPlatelet factor 4-derived C15 peptide broadly inhibits enteroviruses by disrupting viral attachment.
J Virol
January 2025
Department of Infectious Diseases, Center of Infectious Diseases and Pathogen Biology, Institute of Virology and AIDS Research, Key Laboratory of Organ Regeneration and Transplantation of The Ministry of Education, The First Hospital of Jilin University, Changchun, Jilin, China.
Unlabelled: Platelet factor 4 (PF4) has been shown to regulate several viral infections. Our previous study demonstrated that PF4 inhibits the entry of enterovirus A 71 (EV71) and coxsackievirus A16 (CA16), which cause hand, foot, and mouth disease (HFMD). In this study, we report that PF4 also inhibits the circulating HFMD pathogen coxsackievirus A6 (CA6) and the re-emerging enterovirus D68 (EVD68).
View Article and Find Full Text PDFConservative Treatment of Neonatal Brachial Plexus Palsy: A Narrative Review.
J Clin Med
December 2024
Unit of Hand Surgery, Microsurgery and Reconstructive, Department of Orthopaedics and Traumatology, CTO Hospital, 10126 Turin, Italy.
Neonatal brachial plexus palsy (NBPP) is a flaccid paralysis of the upper limbs that occurs in about 0.4 percent of live births. This condition can produce permanent disabilities; to date, there is no consensus on protocols to be applied for the rehabilitation of children with this condition.
View Article and Find Full Text PDFRecent Molecular Epidemiology of Echovirus 11 Throughout North and West Africa Resulted in the First Identification of a Recombinant Strain from an Acute Flaccid Paralysis Case in West Africa.
Viruses
November 2024
Virology Department, Institut Pasteur de Dakar, 36 Avenue Pasteur, Dakar 220, Senegal.
Article Synopsis
- Echovirus 11 is causing increasing cases of neonatal sepsis in Europe and limited reports in West Africa, highlighting a significant public health issue.
- A study analyzed 23 E11 strains from West Africa using high-throughput sequencing, marking the first molecular characterization of the virus in the region and revealing a new recombinant strain.
- The research indicates that E11 has evolved into four distinct clades since the 1970s, with instances of the virus spreading from West Africa to Europe, underscoring the need for enhanced surveillance of enteroviruses in Africa.
Elevated incidence of infant botulism in a 17-county area of the Mid-Atlantic region in the United States, 2000-2019, including association with soil types.
Appl Environ Microbiol
November 2024
Department of Ecosystems Science and Management, Pennsylvania State University, University Park, Pennsylvania, USA.
Unlabelled: We sought to identify counties in the northeastern United States where the incidence of infant botulism (IB) is elevated compared to the nationwide incidence and to assess associations with soil type at the case residence. IB cases were identified through the distribution of the orphan drug Human Botulism Immune Globulin Intravenous for treatment of IB by state and national surveillance systems and were subsequently confirmed by laboratory testing. IB incidence by county was calculated as the number of IB cases divided by the number of live births in the county from 2000 to 2019.
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