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Challenges and Considerations in Diagnosing and Managing p16+-Related Oropharyngeal Squamous Cell Carcinoma (OPSCC) with Neck Metastasis: Implications of p16 Positivity, Tobacco Exposure, and De-Escalation Strategies.
J Clin Med
November 2024
ENT Unit, Department of Mental, Physical Health and Preventive Medicine, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
Background: The incidence of patients showing neck metastasis and no obvious primary tumor at the initial diagnostic evaluation or neck cancer of unknown primary (NCUP) is rising. It is estimated that a relevant part of these tumors arises in the tonsillar crypts or base of the tongue and are p16+-related. However, today, the detection rate of the primary tumor is suboptimal.
View Article and Find Full Text PDFMOGAD: A comprehensive review of clinicoradiological features, therapy and outcomes in 4699 patients globally.
Autoimmun Rev
January 2025
Translational Neuroimmunology Group, Faculty of Medicine and Health, University of Sydney, Kids Neuroscience Centre, Children's Hospital at Westmead, Sydney, Australia; Sydney Medical School and Brain and Mind Centre, Faculty of Medicine and Health, University of Sydney, Sydney, Australia; Department of Neurology, Concord Hospital, Sydney, Australia. Electronic address:
Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is one of the most common antibody-mediated CNS disorders. Optimal diagnostic and prognostic biomarkers remain unclear. Our aim was to clarify these biomarkers and therapeutic outcomes internationally.
View Article and Find Full Text PDFPseudocysts of the Adrenal Gland: A Systematic Review of Existing Scientific Literature From 2000 to 2023.
Cureus
September 2024
General Surgery, Lahore General Hospital, Lahore, PAK.
Article Synopsis
- Adrenal masses include various abnormal growths in the adrenal gland, with pseudocysts being the most common type of cysts; there are currently no specific guidelines for their management due to their rare occurrence.
- A systematic review of 39 studies from 2000 to 2023 focused on the clinical and radiological characteristics of adrenal gland pseudocysts, analyzing data from 45 patients, primarily adult women.
- Findings indicated that many patients were asymptomatic or experienced vague abdominal pain, with the most notable imaging result being cystic lesions with calcifications; surgical intervention was necessary in cases of compression, growth, or cancer suspicion, with a majority undergoing open surgery.
Single-Incision Direct Lateral Approach Versus Dual-Incision Approach for Distal Tibial and Fibular Fractures.
Cureus
September 2024
Department of Orthopaedics, Institute of Medical Sciences and SUM Hospital, Bhubaneswar, IND.
Introduction: Distal tibial and fibular fractures are typically the result of high-energy trauma. Open reduction and internal fixation (ORIF) are often used to reconstruct and reduce displaced fractures, especially intra-articular ones. These fractures can be addressed either by a dual-incision approach (medial approach for the distal tibia and lateral approach for the fibula) or by a single-incision direct lateral approach to fix both the tibia and fibula.
View Article and Find Full Text PDFIntroduction: The occurrence of orthopedic injuries during pregnancy carries considerable morbidity and mortality for both the mother and fetus. Successful care of lower limb fractures during pregnancy requires a multidisciplinary approach. Both operative and non-operative treatments must be taken into account by the treating orthopedic physician.
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