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Candida albicans migrates itself from the vagina to the uterus and ovaries in estrogenized mice.
Braz J Microbiol
January 2025
Department of Clinical Analysis and Biomedicine, Laboratory of Medical Mycology, State University of Maringá, Maringá, Paraná, Brazil.
Vulvovaginal candidiasis (VVC) represents the second cause of vaginal infections in childbearing-age women. It mainly affects the vulva and vagina; however, other organs can be compromised, with consequences that are not well known yet. To evaluate the ability of Candida albicans, inoculated into the vaginal lumen of mice, to migrate to the uterus and ovaries.
View Article and Find Full Text PDFModulation of cytokeratin and cytokine/chemokine expression following influenza virus infection of differentiated human tonsillar epithelial cells.
J Virol
January 2025
Department of Host-Microbe Interactions, St Jude Children's Research Hospital, Memphis, Tennessee, USA.
Unlabelled: The tonsils have been identified as a site of replication for Epstein-Barr virus, adenovirus, human papillomavirus, and other respiratory viruses. Human tonsil epithelial cells (HTECs) are a heterogeneous group of actively differentiating cells. Here, we investigated the cellular features and susceptibility of differentiated HTECs to specific influenza viruses, including expression of avian-type and mammalian-type sialic acid (SA) receptors, viral replication dynamics, and the associated cytokine secretion profiles.
View Article and Find Full Text PDFChemical profile changes in Peanut seeds infected with aspergillus flavus via widely targeted metabolomics.
Food Chem
January 2025
Crops Research Institute, Guangdong Academy of Agricultural Sciences, Guangdong Provincial Key Laboratory of Crop Genetic Improvement, South China Peanut Sub-Center of National Center of Oilseed Crops Improvement, Guangzhou, Guangdong Province 510640, China. Electronic address:
Peanut seeds are enriched with protein and fatty acids, making them susceptible to infection by Aspergillus flavus (A. flavus). The infected seeds are harmful to human health due to the aflatoxin contamination.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Texas Children's Hospital/Baylor College of Medicine, Houston, TX, USA.
Background: Clinical studies in COVID-19 patients have demonstrated evidence of neuroinflammation in patients infected with SARS-CoV-2. In this pre-clinical work, we investigate neuroinflammation in vivo in a mouse model of Alzheimer's disease (AD) that exhibits both amyloid and tau pathology, the 3xTg-AD mice crossed with K18 hAce2 and infected with SARS-CoV-2 using a folate receptor-targeted nanoprobe for molecular MRI (mMRI) followed by ex vivo histopathology.
Method: In vivo studies with SARS-CoV-2 were performed in an animal biosafety level 3 (ABSL3) facility.
Biomarkers.
Alzheimers Dement
December 2024
Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Background: Long-COVID is characterized by persistent symptoms post-infection with SARS-CoV-2. This condition includes neurological manifestations and has been proposed as a potential risk factor for the development of dementia. Individuals presenting with dementia due to Alzheimer's disease have dysfunctional brain metabolism, including metabolic brain network (MBN) hypoconnectivity.
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