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Microbiological and toxicity analyses of the synthetic polymer polyhexamethylene guanidine hydrochloride against endodontic microorganisms.
Braz J Microbiol
January 2025
Department of Postgraduate Program in Animal Science, University of Franca (UNIFRAN), Av. Dr. Armando Salles Oliveira, 201, Parque Universitário, Franca, SP, CEP 14.404-600, Brazil.
Failures in endodontic treatments are common due to microbial resistance in the pulp canal. The study evaluated the in vitro activity of polyhexamethylene guanidine hydrochloride (PHMGH) against endodontic strains, as well as in vivo toxicity. Using minimum inhibitory concentration and minimum bactericidal concentration techniques, PHMGH was effective against all microorganisms, even at low concentrations.
View Article and Find Full Text PDFBacterial Isolates and Their Antimicrobial Susceptibility Patterns Among Pediatric Patients with Urinary Tract Infections: A Retrospective Cross-Sectional Study at Tertiary Level in Afghanistan.
Infect Drug Resist
January 2025
Department of Pathology and Clinical Laboratory, French Medical Institute for Mother and Children (FMIC), Kabul, Afghanistan.
Introduction: The widespread use of antibiotics is a serious and alarming situation in terms of the development of antimicrobial resistance. The current study was conducted to demonstrate the types of organism isolated from the urine of patients presenting with UTI symptoms as well as their antimicrobial sensitivity spectrum.
Methodology: A descriptive cross-sectional study was conducted, and 272 positive urine cultures from children under 5 years of age with signs and symptoms of a UTI were included in the study.
Synthesis, characterization and biological profile of some new dihydropyrimidinone derivaties.
Heliyon
January 2025
Department of Pharmaceutical Chemistry, Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, Pakistan, 44000.
Objective: The rise of drug-resistant bacteria, viruses, and fungi has prompted the search for new drugs without cross-resistance to current treatments. As a result, the aim of this research was to synthesize various types of dihydropyrimidinones heterocyclic compounds and screened them for their antibiotic properties.
Methodology: Newly synthesized dihydropyrimidinone derivatives were characterized spectroscopically using proton NMR (HNMR), and FT-IR.
Impact of Fluconazole Resistance on the Outcomes of Patients With Candida parapsilosis Bloodstream Infections: A Retrospective Multicenter Study.
Clin Infect Dis
January 2025
Infectious Diseases Unit, Policlinico San Martino Hospital-IRCCS, Genoa, Italy.
Background: This study assesses the impact of fluconazole resistance on 30-day all-cause mortality and 1-year recurrence in patients with Candida parapsilosis bloodstream infections (BSI).
Methods: A multicenter retrospective study was performed at 3 hospitals in Italy and Spain between 2018 and 2022. Adult patients with positive blood cultures for C.
Incidence, Distribution, and Pathogenicity of Fungi Growing on Sugar Beet Roots on Top of Outdoor Piles in Idaho.
Plant Dis
January 2025
USDA ARS, Northwest Irrigation and Soils Research Laboratory, 3793 North 3600 East, Kimberly, Idaho, United States, 83341;
Sugar beet roots in Idaho are held under ambient conditions in outdoor storage piles which can lead to fungal growth and rot and substantial sucrose loss. Thus the incidence, distribution, and pathogenicity of fungi associated with fungal growth on the surface of sugar beet roots on top of outdoor piles was investigated. The surface fungal growth on sugar beet roots held on top of 14 Idaho outdoor piles [tarped ventilated (TV) piles and piles with no tarps or ventilation (NTV) at 7 locations] was assessed in 2018-19 and 2019-20.
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