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DNA targeting by compact Cas9d and its resurrected ancestor.
Nat Commun
January 2025
Interdisciplinary Life Sciences Graduate Programs, University of Texas at Austin, Austin, TX, 78712, USA.
Type II CRISPR endonucleases are widely used programmable genome editing tools. Recently, CRISPR-Cas systems with highly compact nucleases have been discovered, including Cas9d (a type II-D nuclease). Here, we report the cryo-EM structures of a Cas9d nuclease (747 amino acids in length) in multiple functional states, revealing a stepwise process of DNA targeting involving a conformational switch in a REC2 domain insertion.
View Article and Find Full Text PDFEffect of traditional Chinese Yijinjing exercise on hand dysfunction in rheumatoid arthritis patients: a randomized controlled trial.
Front Med (Lausanne)
November 2024
Department of Medical Affairs, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Article Synopsis
- This study evaluated the effects of Yijinjing, a traditional Chinese exercise, on hand dysfunction in patients with rheumatoid arthritis (RA) over 12 weeks.
- Participants were randomly assigned to either the Yijinjing exercise group or a control group, with various health outcomes measured before and after the intervention.
- Results showed significant improvements in hand functionality, strength, and overall quality of life for the Yijinjing group, without any negative side effects observed.
In Vivo Test to Evaluate the Cytotoxicity and Genotoxicity of Natural Zeolite (NZ) Functionalized with Silver Nanoparticles (NZ-AgNPs) on Erythrocytes of Yellowtail Tetra Fish Astyanax lacustris.
Biol Trace Elem Res
November 2024
Graduate Program of Environmental Biotechnology, Department of Biotechnology, Genetics and Cell Biology, State University of Maringá, Maringá, Paraná, Brazil.
Silver nanoparticles (AgNPs) have unique properties such as chemical stability, malleability, flexibility, high electrical and thermal conductivity, and catalytic activity, making them suitable for various applications. However, they also pose potential toxicity and environmental contamination risks. Natural zeolites (NZs) are considered excellent inorganic support for reducing the toxicity of AgNPs.
View Article and Find Full Text PDF[High stability enhanced ultrasonic microfluidic structure with flexible tip coupled bubbles].
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi
October 2024
Key Lab of Microelectronic Devices & Integrated Technology, Institute of Microelectronics, Chinese Academy of Sciences, Beijing 100029, P. R. China.
Ultrasonic microfluidic technology is a technique that couples high-frequency ultrasonic excitation to microfluidic chips. To improve the issues of poor disturbance effects with flexible tip structures and the susceptibility of bubbles to thermal deformation, we propose an enhanced ultrasonic microchannel structure that couples flexible tips with bubbles aiming to improve the disturbance effects and the stability duration. Firstly, we used finite element analysis to simulate the flow field distribution characteristics of the flexible tip, the bubble, and the coupling structure and obtained the steady-state distribution characteristics of the velocity field.
View Article and Find Full Text PDFBiomechanics of phagocytosis of red blood cells by macrophages in the human spleen.
Proc Natl Acad Sci U S A
October 2024
Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
The clearance of senescent and altered red blood cells (RBCs) in the red pulp of the human spleen involves sequential processes of prefiltration, filtration, and postfiltration. While prior work has elucidated the mechanisms underlying the first two processes, biomechanical processes driving the postfiltration phagocytosis of RBCs retained at interendothelial slits (IES) are still poorly understood. We present here a unique computational model of macrophages to study the role of cell biomechanics in modulating the kinetics of phagocytosis of aged and diseased RBCs retained in the spleen.
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