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Impact of Thrombophilia Testing on Clinical Management: A Retrospective Cohort Study.
Hamostaseologie
December 2024
Institute for Experimental Hematology and Transfusion Medicine, University Hospital Bonn, Bonn, Germany.
Thrombophilia management is based on the personal and family history of thrombosis. Current guidelines recommend performing thrombophilia testing only when the results will change clinical management. To investigate to what extent treatment recommendations changed following thrombophilia testing, clinical and laboratory data of 255 patients with and without venous thromboembolism who underwent thrombophilia screening were assessed retrospectively.
View Article and Find Full Text PDFUnveiling the Unexpected: Lung Adenocarcinoma Presenting With Penile Mondor's Disease and Multiple Thrombotic Complications.
Cureus
October 2024
Respiratory Medicine, Iizuka Hospital, Iizuka, JPN.
Article Synopsis
- Penile Mondor's disease (PMD) is a rare and usually benign condition caused by thrombophlebitis of the superficial dorsal vein of the penis, but in this case, it was a sign of lung adenocarcinoma.
- A 46-year-old Japanese man initially presented with PMD, which led to the diagnosis of advanced stage IVA lung cancer, complicated by deep vein thrombosis and nonbacterial thrombotic endocarditis.
- This case emphasizes the need for doctors to consider potential underlying cancers in patients with unusual clotting issues, as well as the varied ways cancer can present itself.
Venous thromboembolism in patients with hairy cell leukemia.
Hematology
December 2024
Guthrie Robert Packer Hospital, Sayre, PA, USA.
Background: Hairy cell leukemia (HCL) is rare leukemia of mature B cells, accounting for 2% of all lymphoid neoplasms. Although the association of venous thromboembolism (VTE) with cancer is well established, there is no systematic study describing VTE in HCL.
Aim: To analyze prevalence and risk factors associated with VTE in HCL patients.
The Basic Principles of Pathophysiology of Venous Thrombosis.
Int J Mol Sci
October 2024
Center of Pathology of Pregnancy and Hemostasis «Medlabi», Tbilisi 340112, Georgia.
Article Synopsis
- Recent developments have improved our understanding of the molecular processes that lead to thrombus formation, particularly regarding deep vein thrombosis (DVT), which can be triggered by various factors like trauma, immobility, or genetic issues.
- About half of DVT cases are unprovoked, involving mechanisms such as venous stasis and hypoxia, raising the importance of immunothrombosis, especially during conditions like COVID-19 that exacerbate inflammation and promote microthrombi formation.
- Research involving animal models and clinical studies has revealed the intricate relationship between immune cells, blood components, and various factors influencing coagulation, providing a deeper insight into the causes of hypercoagulability and venous thromboembolism.
Perinatal outcomes in indian women with Antiphospholipid Antibody Syndrome (APS): Five year experience from a tertiary care centre.
Eur J Obstet Gynecol Reprod Biol X
December 2024
Department of Obstetrics and Gynaecology, PGIMER Chandigarh, 160012, India.
Background: Antiphospholipid Syndrome (APS) is a systemic autoimmune thrombophilic condition characterized by obstetric manifestations, including pregnancy loss, preeclampsia and fetal growth restriction. Early diagnosis and management are key to improve maternal and neonatal outcomes.
Objective: The aim of this study is to assess the perinatal outcomes in APS, the development of various adverse pregnancy outcomes (APO), and their association with specific antibody profiles.
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