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Microb Cell Fact
January 2025
Biotechnological Processes Unit, IMDEA Energy, 28935, Móstoles (Madrid), Spain.
Environmental concerns are rising the need to find cost-effective alternatives to fossil oils. In this sense, short-chain fatty acids (SCFAs) are proposed as carbon source for microbial oils production that can be converted into oleochemicals. This investigation took advantage of the outstanding traits of recombinant Yarrowia lipolytica strains to assess the conversion of SCFAs derived from real digestates into odd-chain fatty acids (OCFA).
View Article and Find Full Text PDFJ Nanobiotechnology
January 2025
Department of Orthopedic Surgery, Fujian Medical University Union Hospital, Fuzhou, 350001, China.
Overproduction of reactive oxygen species (ROS), elevated synovial inflammation, synovial hyperplasia and fibrosis are the main characteristic of microenvironment in rheumatoid arthritis (RA). Macrophages and fibroblast-like synoviocytes (FLSs) play crucial roles in the progression of RA. Hence, synergistic combination of ROS scavenging, macrophage polarization from pro-inflammatory M1 phenotype towards M2 anti-inflammatory phenotype, and restoring homeostasis of FLSs will provide a promising therapeutic strategy for RA.
View Article and Find Full Text PDFJ Nanobiotechnology
January 2025
School of Medical Imaging, Xuzhou Medical University, Xuzhou, 221004, China.
With the progress of atherosclerosis (AS), the arterial lumen stenosis and compact plaque structure, the thickening intima and the narrow gaps between endothelial cells significantly limit the penetration efficiency of nanoprobe to plaque, weakening the imaging sensitivity and therapy efficiency. Thus, in this study, a HO-NIR dual-mode nanomotor, Gd-doped mesoporous carbon nanoparticles/Pt with rapamycin (RAPA) loading and AntiCD36 modification (Gd-MCNs/Pt-RAPA-AC) was constructed. The asymmetric deposition of Pt on Gd-MCNs catalyzed HO at the inflammatory site to produce O, which could promote the self-motion of the nanomotor and ease inflammation microenvironment of AS plaque.
View Article and Find Full Text PDFNat Chem Biol
January 2025
Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Diverse bacteria and archaea use atmospheric CO as an energy source for long-term survival. Bacteria use [MoCu]-CO dehydrogenases (Mo-CODH) to convert atmospheric CO to carbon dioxide, transferring the obtained electrons to the aerobic respiratory chain. However, it is unknown how these enzymes oxidize CO at low concentrations and interact with the respiratory chain.
View Article and Find Full Text PDFSci Rep
January 2025
Faculty of Social Sciences, University of Lodz, ul. Prez, prez. Gabriela Narutowicza 68, 90-136, Łódź, Poland.
Based on a balanced panel dataset of 272 prefecture-level cities from 2000 to 2022, this paper systematically investigates the impact of the carbon emissions trading system on green total factor productivity and its underlying mechanisms from an integrated perspective of overall, dynamic, and spatial dimensions. The findings reveal that (1) the carbon emissions trading system significantly enhances regional total factor productivity, primarily by optimizing resource allocation efficiency and strengthening regional competitiveness. (2) From a dynamic perspective, the policy effect exhibited a U-shaped relationship: from 2013 to 2018, green total factor productivity was suppressed due to underdeveloped market mechanisms and the policy environment; after 2018, with market maturation and policy stabilization, the policy effects improved significantly.
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