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Astrocyte-derived PTN alleviates deficits in hippocampal neurogenesis and cognition in models of multiple sclerosis.
Stem Cell Reports
January 2025
Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Guangzhou 510630, Guangdong Province, China. Electronic address:
Multiple sclerosis (MS) is an autoimmune inflammatory demyelinating disease that results in motor, sensory, cognitive, and affective deficits. Hippocampal demyelination, a common occurrence in MS, is linked to impaired cognitive function and mood. Despite this, the precise mechanisms underlying cognitive impairments in MS remain elusive.
View Article and Find Full Text PDFGene Expression and Alternative Splicing Analysis in a Large-Scale Multiple Sclerosis Study.
Int J Mol Sci
November 2024
Kentucky IDeA Networks of Biomedical Research Excellence Bioinformatics Core, Department of Biochemistry and Molecular Genetics, University of Louisville, Louisville, KY 40292, USA.
Multiple Sclerosis (MS) is an autoimmune neurodegenerative disease affecting approximately 3 million people globally. Despite rigorous research on MS, aspects of its development and progression remain unclear. We utilized a publicly available RNA-seq dataset (GSE138614) consisting of the post-mortem white matter tissues of five donors without any neurological disorders and ten MS patient donors.
View Article and Find Full Text PDFEtiology and characteristics of pseudotumoral lesions and tumefactive demyelination in multiple sclerosis.
Mult Scler Relat Disord
December 2024
Faculty of Medicine, University of Belgrade, Serbia; Neurology Clinic, University Clinical Center of Serbia, Serbia. Electronic address:
Article Synopsis
- The study focused on cerebral pseudotumoral lesions (CPTL) greater than 2 cm, primarily in patients referred for evaluation of multiple sclerosis (MS).
- Most of the 75 patients studied had MS (58.7%), with relapsing disease and specific lesion characteristics being significantly more common in this group compared to non-MS patients.
- Key indicators such as headache, the nature of disease progression, and certain MRI traits could help differentiate between MS and non-MS conditions, suggesting a need for further research with larger sample sizes.
Increased angiopoietin-1 improves nailfold capillary morphology in patients with systemic sclerosis.
Microvasc Res
January 2025
Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan.
Objective: Raynaud's phenomenon is a common symptom of systemic sclerosis. We previously reported that elbow heating increases angiopoietin-1 in the fingertips and alleviates Raynaud's phenomenon. Angiopoietin-1 levels decrease in patients with systemic sclerosis with severe capillary damage.
View Article and Find Full Text PDFA Report of a Case of Reactivation of Plaque Morphea After Sunlight Exposure and a Literature Review.
Cureus
October 2024
Dermatology and Venereology, Medical University of Plovdiv, Plovdiv, BGR.
We present the case of a 61-year-old woman with a histopathologically confirmed diagnosis of plaque morphea. The disease began about four years ago with the appearance of a single oval sclerotic plaque located on the front surface of the right lower leg. After topical treatment, the plaque underwent reverse development.
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