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Phosphorylation-Induced Self-Coacervation versus RNA-Assisted Complex Coacervation of Tau Proteins.
J Am Chem Soc
March 2025
Institute of Biological Chemistry, Academia Sinica, No. 128, Sec. 2, Academia Road, Nankang, Taipei 115, Taiwan.
In this study, the role of phosphorylation in the liquid-liquid phase separation (LLPS) of tau, the underlying driving forces, and the potential implications of this separation on protein conformation and subsequent protein aggregation were investigated. We compared in vivo-produced phosphorylated tau (p-tau) and nonphosphorylated tau under different coacervation conditions without adding crowding agents. Our findings revealed that spontaneous phase separation occurs exclusively in p-tau, triggered by a temperature shift from 4 °C to room temperature, and is driven by electrostatic and hydrophobic interactions.
View Article and Find Full Text PDFDeep-Learning-Assisted Understanding of the Self-Assembly of Miktoarm Star Block Copolymers.
ACS Nano
March 2025
School of Chemical Science and Engineering, Tongji University, 1239 Siping Road, Shanghai 200092, China.
The self-assemblies of topological complex block copolymers, especially the AB type miktoarm star ones, are fascinating topics in the soft matter field, which represent typical self-assembly behaviors analogous to those of biological membranes. However, their diverse topological asymmetries and versatile spontaneous curvatures result in rather complex phase separations that deviate significantly from the common mechanisms. Thus, numerous trial-and-error experiments with tremendous parameter space and intricate relationships are needed to study their assemblies.
View Article and Find Full Text PDFMorphological and genetic diversity assessment of cultivated Thymus satureioides (endemic species) of Morocco.
J Genet Eng Biotechnol
March 2025
National Institute of Agricultural Research (INRA), Regional Center of Agricultural Research Rabat, Biotechnology Unit, Rabat 10000 Morocco.
Thymus satureioides is an endemic and medicinal plant of Morocco, widely distributed in the arid and semiarid habitats. Communally used in traditional medicine. In the current study, twelve Inter-Simple Sequence Repeats (ISSR) primers combined with 11 agro-morphological traits were applied to evaluate 60 accessions of T.
View Article and Find Full Text PDF1-Octen-3-ol exacerbates depression-induced neurotoxicity via the TLR4/NF-κB and Nrf2/HO-1 pathways.
Neurotoxicology
March 2025
Collaborative Innovation Center for Modern Grain Circulation and Safety, and College of Food Science and Engineering, Nanjing University of Finance and Economics, Nanjing, 210023, China; Jiangsu Province Engineering Research Center of Edible Fungus Preservation and Intensive Processing, Nanjing 210023, China. Electronic address:
1-Octen-3-ol is a volatile compound widely found in various fungi and plants, and studies have suggested its potential role in the development of neurodegenerative diseases. However, the mechanism by which 1-octen-3-ol induces neural injury in rats remains unclear. In this study, we used aerosolized 1-octen-3-ol to treat depressive model rats to investigate its effects on neural injury behaviors and neurophysiology in SD rats.
View Article and Find Full Text PDFThe patient was a 51-year-old man who was diagnosed as having prostate cancer(adenocarcinoma)in December Year X-3. He underwent total prostatectomy in June Year X-2. The lesions were confined to the right lobe of the prostate.
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