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Conformational dynamics of the membrane protein of MERS-CoV in comparison with SARS-CoV-2 in ERGIC complex.
J Biomol Struct Dyn
January 2025
College of Applied Medical Sciences, lmam Abdulrahman Bin Faisal University (lAU), Dammam, Saudi Arabia.
The present study explores the conformational dynamics of the membrane protein of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) within the Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) complex using an all-atomistic molecular dynamics simulation approach. Significant structural changes were observed in the N-terminal, C-terminal, transmembrane, and beta-sheet sandwich domains of the MERS-CoV membrane protein. This study also highlights the structural similarities between the MERS-CoV and the SARS-CoV-2 membrane proteins, particularly in how both exhibit a distinct kink in the transmembrane helix caused by aromatic residue-lipid interactions.
View Article and Find Full Text PDFInhibitory mechanisms of galloylated forms of theaflavins on α-glucosidase.
Int J Biol Macromol
January 2025
School of Biological and Chemical Engineering, NingboTech University, Ningbo 315100, China. Electronic address:
Theaflavins, oxidation product of tea polyphenols, have demonstrated significant inhibitory effects on α-glucosidase, which is beneficial in alleviating hyperglycemia. This study found that the inhibition of four monomers of theaflavins on α-glucosidase was related to the presence of the galloyl moiety (GM), with IC values ranging from TFDG (0.26 mg/mL) < TF3'G (0.
View Article and Find Full Text PDFRevealing the mechanism underlying the viscosity improvement of rice protein yogurt by the presence of in-situ-produced dextrans.
Int J Biol Macromol
January 2025
College of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei Province 430070, PR China. Electronic address:
The in-situ-produced dextrans (DXs) could effectively enhance the viscosity of rice protein (RP) yogurt, but the reason for this improvement has not been elucidated. This study aims to reveal the mechanism underlying the viscosity improvement of RP yogurt by the presence of in-situ DXs. DXs synthesized in RP yogurts under different optimum conditions were purified and fully characterized.
View Article and Find Full Text PDFPeptide toxins as tools in ion channel biology.
Curr Opin Chem Biol
January 2025
Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Bhopal, Bhopal Bypass Road, Bhauri, Bhopal, 462066, Madhya Pradesh, India; Department of Chemistry, Indian Institute of Science Education and Research (IISER) Bhopal, Bhopal Bypass Road, Bhauri, Bhopal, 462066, Madhya Pradesh, India. Electronic address:
Animal venom contains ion channel-targeting peptide toxins that inflict paralysis or pain. The high specificity and potency of these toxins for their target ion channels provides enticing opportunities for their deployment as tools in channel biology. Mechanistic studies on toxin-mediated ion channel modulation have yielded landmark breakthroughs in our understanding of channel architectures and gating mechanisms.
View Article and Find Full Text PDFEffects of in vitro simulated digestion on the hypoglycaemic capacity of wheat bran-soluble dietary fibre.
Biochem Biophys Res Commun
December 2024
College of Food Science and Engineering, Nanjing University of Finance and Economics, Nanjing, 210023, China. Electronic address:
Wheat bran-soluble dietary fibre (WB-SDF) is known for its hypoglycaemic properties and its potential to control postprandial blood glucose levels in individuals with hyperglycaemia. However, the digestive process may alter its glucose-lowering potential. This study investigated the effects of in vitro simulated digestion on the hypoglycaemic efficacy of WB-SDF.
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