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Human immunodeficiency virus-associated vacuolar encephalomyelopathy with granulomatous-lymphocytic interstitial lung disease improved after antiretroviral therapy: a case report.
AIDS Res Ther
July 2020
Department of Respiratory Medicine, Nagasaki University Hospital, Sakamoto 1-7-1, Nagasaki City, Nagasaki, 852-8501, Japan.
Article Synopsis
- - Vacuolar encephalomyelopathy, previously significant in late-stage HIV-1 infections, is now being acknowledged again, especially in a case involving a newly diagnosed HIV-infected man who also had granulomatous-lymphocytic interstitial lung disease (GLILD).
- - The 40-year-old patient exhibited symptoms like chronic cough and paraplegia, with tests revealing lung and brain abnormalities; he was diagnosed with both GLILD and HIV-associated vacuolar encephalomyelopathy based on specific medical examinations.
- - Following the start of antiretroviral therapy (ART), the patient showed marked improvement in neurological symptoms and respiratory conditions, underscoring the necessity of considering these diagnoses in HIV patients even
Graves' disease in a 3 year-old patient with agranulocytosis due to anti-thyroid drugs: Radioiodine ablation therapy as an effective alternative.
Rev Esp Med Nucl Imagen Mol
June 2018
Unidad de Gestión Clínica de Medicina Nuclear, Hospital Regional Universitario de Málaga, Málaga, España.
The case is presented of a 3 year-old girl with mitochondrial disease (subacute necrotizing encephalomyelopathy of Leigh syndrome), v-stage chronic kidney disease of a diffuse mesangial sclerosis, as well as developmental disorders, and diagnosed with hyperthyroidism Graves-Basedow disease. Six weeks after starting the treatment with neo-carbimazole, the patient reported a serious case of agranulocytosis. This led to stopping the anti-thyroid drugs, and was treated successfully with I ablation therapy.
View Article and Find Full Text PDFHepatic encephalomyelopathy: a complication following liver cirrhosis caused by Budd-Chiari syndrome and HBV.
J Infect Dev Ctries
April 2014
The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.
Progressive encephalomyelopathy is a rare neurological complication of chronic liver disease, even manifesting progressive spastic paraparesis. Few reports detailing the clinical and diagnostic aspects of this uncommon cause of neurological deterioration in patients with hepatic insufficiency have been published. Early recognition of this disorder will become more important in the future as patients with liver disease survive longer due to medical advances, including liver transplantation.
View Article and Find Full Text PDFCurrent pathways for epidemiological research in amyotrophic lateral sclerosis.
Amyotroph Lateral Scler Frontotemporal Degener
May 2013
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disease. The current status of the epidemiology, challenges to its study, and novel study design options are discussed in this paper. We focus on recent results from large-scale population based prospective studies, case-control studies and population based registries, risk factors, and neuropathologic findings in chronic traumatic encephalomyelopathy.
View Article and Find Full Text PDFHTLV-1 infection: what determines the risk of inflammatory disease?
Trends Microbiol
October 2012
Imperial College London, Department of Immunology, Norfolk Place, London W2 1PG, UK.
Human T-lymphotropic virus type 1 (HTLV-1) is an exogenous retrovirus that persists lifelong in the infected host. Infection has been linked to a spectrum of diverse diseases: adult T cell leukemia, encephalomyelopathy, and predisposition to opportunistic bacterial and helminth infections. Applications of new technologies and biological concepts to the field have provided new insights into viral persistence and pathogenesis in HTLV-1 infection.
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